SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 PHE A  46
LYS A 281
LYS A 280
ALA A 279
 None
 0.94A 1hk2A-4mcoA:
undetectable		 1hk2A-4mcoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		5 / 12 THR A 214
GLY A 154
GLY A 234
GLN A 152
ASN A 198
 MLI  A 401 (-3.8A)
None
None
MLI  A 401 ( 4.3A)
None
 1.29A 1n2xA-4mcoA:
2.0		 1n2xA-4mcoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		5 / 12 LEU A 108
ASN A 109
GLY A 111
LEU A 146
MET A 247
 None
 1.32A 1nhzA-4mcoA:
undetectable		 1nhzA-4mcoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 7 LYS A 142
GLU A 141
LEU A  98
ALA A 101
 None
 1.00A 1sn0B-4mcoA:
undetectable
1sn0D-4mcoA:
undetectable		 1sn0B-4mcoA:
18.15
1sn0D-4mcoA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 PHE A  54
VAL A 267
PHE A  68
MET A  66
 None
 1.06A 1wrlB-4mcoA:
undetectable		 1wrlB-4mcoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		5 / 10 ASP A 319
GLU A 180
GLY A 321
ILE A 184
ALA A 312
 None
 1.11A 1x7pA-4mcoA:
undetectable
1x7pB-4mcoA:
undetectable		 1x7pA-4mcoA:
20.56
1x7pB-4mcoA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 PHE A 219
ILE A 200
GLY A 176
GLY A 177
 None
None
None
MLI  A 401 ( 4.9A)
 0.73A 2qx6A-4mcoA:
undetectable
2qx6B-4mcoA:
undetectable		 2qx6A-4mcoA:
21.08
2qx6B-4mcoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 8 PHE A 219
ALA A 157
ALA A 211
LEU A 185
 None
 0.97A 3l4dD-4mcoA:
undetectable		 3l4dD-4mcoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		3 / 3 LYS A 280
LEU A 276
ALA A 279
 None
 0.68A 4ikiA-4mcoA:
undetectable		 4ikiA-4mcoA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		5 / 11 VAL A 227
ALA A 203
THR A 214
ARG A 223
THR A 206
 EPE  A 403 (-4.6A)
None
MLI  A 401 (-3.8A)
None
None
 1.44A 4kyaA-4mcoA:
undetectable		 4kyaA-4mcoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		5 / 11 VAL A 227
ALA A 203
THR A 214
ARG A 223
THR A 206
 EPE  A 403 (-4.6A)
None
MLI  A 401 (-3.8A)
None
None
 1.42A 4kyaE-4mcoA:
undetectable		 4kyaE-4mcoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		5 / 11 VAL A 227
ALA A 203
THR A 214
ARG A 223
THR A 206
 EPE  A 403 (-4.6A)
None
MLI  A 401 (-3.8A)
None
None
 1.43A 4kyaG-4mcoA:
undetectable		 4kyaG-4mcoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  45
SER A 215
ALA A 278
PHE A 274
 None
MLI  A 401 (-2.8A)
None
None
 0.95A 4nedA-4mcoA:
1.9		 4nedA-4mcoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 GLU A 226
GLY A 234
ASP A 283
GLY A 155
 None
 0.54A 5cdnA-4mcoA:
undetectable
5cdnB-4mcoA:
undetectable		 5cdnA-4mcoA:
20.73
5cdnB-4mcoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 GLU A 226
GLY A 234
ASP A 283
GLY A 155
 None
 0.55A 5cdnR-4mcoA:
undetectable
5cdnS-4mcoA:
undetectable		 5cdnR-4mcoA:
20.73
5cdnS-4mcoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 GLU A 226
GLY A 234
ASP A 283
GLY A 155
 None
 0.58A 5cdnC-4mcoA:
undetectable
5cdnD-4mcoA:
undetectable		 5cdnC-4mcoA:
20.73
5cdnD-4mcoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Rhodoferax
ferrireducens) 		4 / 6 GLU A 226
GLY A 234
ASP A 283
GLY A 155
 None
 0.55A 5cdnT-4mcoA:
undetectable
5cdnU-4mcoA:
undetectable		 5cdnT-4mcoA:
20.73
5cdnU-4mcoA:
20.29