SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4mct KILLER PROTEIN
(Proteus
vulgaris) 		4 / 5 ILE B  30
ARG B  33
ARG B  29
ASP B  26
 None
 1.48A 2rhmB-4mctB:
undetectable		 2rhmB-4mctB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4mct ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		5 / 10 ALA B  40
GLU B  45
ILE A  13
LEU A  48
THR B  41
 None
 1.13A 2w3aB-4mctB:
undetectable		 2w3aB-4mctB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4mct ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		4 / 7 LEU A  60
GLU B  45
LEU B  46
MET A  20
 None
 1.15A 2w8yA-4mctA:
undetectable		 2w8yA-4mctA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4mct ANTIDOTE PROTEIN
(Proteus
vulgaris) 		5 / 10 THR A  37
VAL A  33
ILE A  31
ILE A  56
SER A  53
 None
 1.46A 3kpbD-4mctA:
undetectable		 3kpbD-4mctA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4mct KILLER PROTEIN
(Proteus
vulgaris) 		5 / 10 THR B  19
GLY B   9
LEU B  13
LEU B  10
ILE B  30
 None
 1.10A 3kvrB-4mctB:
undetectable		 3kvrB-4mctB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4mct ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		4 / 5 THR A  63
PHE A  66
ARG B  48
LEU A  60
 None
 1.38A 3qelC-4mctA:
undetectable		 3qelC-4mctA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4mct KILLER PROTEIN
(Proteus
vulgaris) 		4 / 5 LEU B  13
PRO B  23
VAL B  22
ASP B  28
 None
 1.10A 3ufnA-4mctB:
undetectable
3ufnB-4mctB:
undetectable		 3ufnA-4mctB:
22.55
3ufnB-4mctB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mct KILLER PROTEIN
(Proteus
vulgaris) 		5 / 12 LEU B  86
LEU B  10
ILE B   2
SER B  20
THR B  19
 None
 1.11A 4f4dB-4mctB:
undetectable		 4f4dB-4mctB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 4mct ANTIDOTE PROTEIN
(Proteus
vulgaris) 		5 / 9 VAL A  33
VAL A  38
PHE A  27
ILE A  13
LEU A  52
 None
 1.05A 5e4dA-4mctA:
undetectable		 5e4dA-4mctA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4mct ANTIDOTE PROTEIN
(Proteus
vulgaris) 		5 / 11 VAL A  33
VAL A  38
PHE A  27
ILE A  13
LEU A  52
 None
 1.10A 5e4dB-4mctA:
undetectable		 5e4dB-4mctA:
19.05