SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4mcx ANTIDOTE PROTEIN
(Proteus
vulgaris) 		5 / 10 ALA A  36
THR A  37
VAL A  38
HIS A   8
ALA A  43
 None
 1.17A 1r55A-4mcxA:
undetectable		 1r55A-4mcxA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		5 / 10 ALA B  40
GLU B  45
ILE A  13
LEU A  48
THR B  41
 None
 1.13A 2w3aB-4mcxB:
undetectable		 2w3aB-4mcxB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris;
Proteus
vulgaris) 		4 / 5 HIS A   8
SER A   7
ARG B  29
ASP A  16
 None
 1.26A 3okxA-4mcxA:
undetectable		 3okxA-4mcxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		4 / 5 THR A  63
PHE A  66
ARG B  48
LEU A  60
 None
 1.38A 3qelC-4mcxA:
undetectable		 3qelC-4mcxA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4mcx KILLER PROTEIN
(Proteus
vulgaris) 		4 / 5 LEU B  13
PRO B  23
VAL B  22
ASP B  28
 None
 1.11A 3ufnA-4mcxB:
undetectable
3ufnB-4mcxB:
undetectable		 3ufnA-4mcxB:
20.51
3ufnB-4mcxB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4mcx KILLER PROTEIN
(Proteus
vulgaris) 		5 / 7 PHE B  78
ASN B  47
GLY B  44
ILE B  37
PHE B  76
 None
 1.36A 4ejjA-4mcxB:
undetectable		 4ejjA-4mcxB:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		4 / 6 ARG A  15
ALA A  14
ASP B  32
LEU A  42
 None
 1.07A 4ot2A-4mcxA:
undetectable		 4ot2A-4mcxA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		4 / 6 ARG B  48
ARG B  33
ARG A  15
ASP A  19
 None
 1.35A 4xqeA-4mcxB:
undetectable		 4xqeA-4mcxB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris) 		4 / 6 ARG B  48
ARG B  33
ARG A  15
ASP A  19
 None
 1.33A 4xqeB-4mcxB:
undetectable		 4xqeB-4mcxB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 4mcx ANTIDOTE PROTEIN
(Proteus
vulgaris) 		5 / 9 VAL A  33
VAL A  38
PHE A  27
ILE A  13
LEU A  52
 None
 1.09A 5e4dA-4mcxA:
undetectable		 5e4dA-4mcxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4mcx ANTIDOTE PROTEIN
KILLER PROTEIN
(Proteus
vulgaris;
Proteus
vulgaris) 		5 / 12 LEU B  86
ILE B  30
ALA B  40
MET A  12
LEU B  46
 None
 1.18A 6ie8A-4mcxB:
undetectable		 6ie8A-4mcxB:
19.35