SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 HIS A 293
ALA A 289
PHE A 288
GLY A 292
 None
 1.19A 1mj2B-4mdaA:
undetectable		 1mj2B-4mdaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 HIS A 293
ALA A 289
PHE A 288
GLY A 292
 None
 1.18A 1mj2D-4mdaA:
undetectable		 1mj2D-4mdaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 HIS A 293
ALA A 289
PHE A 288
GLY A 292
 None
 1.20A 1mjoB-4mdaA:
undetectable		 1mjoB-4mdaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 HIS A 293
ALA A 289
PHE A 288
GLY A 292
 None
 1.22A 1mjoA-4mdaA:
undetectable		 1mjoA-4mdaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 HIS A 293
ALA A 289
PHE A 288
GLY A 292
 None
 1.18A 1mjoD-4mdaA:
undetectable		 1mjoD-4mdaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.38A 2hrcA-4mdaA:
undetectable		 2hrcA-4mdaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.36A 3hcoB-4mdaA:
undetectable		 3hcoB-4mdaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 5 ASP A 156
ASP A 249
TYR A 276
PRO A 278
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.6A)
RLT  A 403 ( 4.9A)
 0.73A 3l2uA-4mdaA:
9.6		 3l2uA-4mdaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 5 ASP A 156
ASP A 249
TYR A 276
PRO A 278
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.6A)
RLT  A 403 ( 4.9A)
 0.75A 3l2wA-4mdaA:
9.6		 3l2wA-4mdaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 8 ASP A 156
ASP A 249
TYR A 276
PRO A 278
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.6A)
RLT  A 403 ( 4.9A)
 0.83A 3s3mA-4mdaA:
10.2		 3s3mA-4mdaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 8 ASP A 156
ASP A 249
TYR A 276
PRO A 278
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.6A)
RLT  A 403 ( 4.9A)
 0.92A 3s3nA-4mdaA:
10.4		 3s3nA-4mdaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 7 ASP A 156
ASP A 249
TYR A 276
PRO A 278
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.6A)
RLT  A 403 ( 4.9A)
 0.83A 3s3oA-4mdaA:
10.3		 3s3oA-4mdaA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		5 / 6 ASP A 156
ASP A 249
ASN A 250
ALA A 274
ASP A 284
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.4A)
None
MN  A 402 ( 2.0A)
 1.39A 4mdbA-4mdaA:
35.2		 4mdbA-4mdaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		6 / 6 ASP A 156
ASP A 249
ASN A 250
ALA A 275
TYR A 276
ASP A 284
 MN  A 401 (-2.6A)
MN  A 401 ( 2.7A)
RLT  A 403 (-3.4A)
RLT  A 403 (-2.9A)
RLT  A 403 (-3.6A)
MN  A 402 ( 2.0A)
 0.57A 4mdbA-4mdaA:
35.2		 4mdbA-4mdaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 8 ILE A 245
HIS A 273
PHE A 148
THR A 135
 None
 0.90A 4n16A-4mdaA:
undetectable		 4n16A-4mdaA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 6 ARG A 132
ARG A 332
ASP A 279
VAL A 337
 None
 1.42A 4xqeA-4mdaA:
undetectable		 4xqeA-4mdaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mda MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		3 / 3 ARG A 151
PHE A 246
PHE A 148
 None
 1.07A 6nknC-4mdaA:
undetectable
6nknJ-4mdaA:
undetectable		 6nknC-4mdaA:
18.12
6nknJ-4mdaA:
16.40