SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mdp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 GLY A 423
ASP A   6
ALA A 426
SER A  72
LEU A  65
 None
 1.40A 1kiaD-4mdpA:
undetectable		 1kiaD-4mdpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 9 TYR A 424
PHE A 403
TYR A 308
ALA A  12
GLU A 377
 None
None
GOL  A 507 (-4.1A)
None
GOL  A 507 (-3.8A)
 1.28A 1mrgA-4mdpA:
undetectable		 1mrgA-4mdpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 6 ASP A 431
TYR A 447
ASP A 449
GLU A 437
 None
 0.94A 1rjdA-4mdpA:
2.3		 1rjdA-4mdpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 6 ASP A 431
TYR A 447
ASP A 449
GLU A 437
 None
 0.93A 1rjdB-4mdpA:
undetectable		 1rjdB-4mdpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 6 ASP A 431
TYR A 447
ASP A 449
GLU A 437
 None
 0.95A 1rjdC-4mdpA:
undetectable		 1rjdC-4mdpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 11 ASN A 165
GLU A 166
TYR A 308
GLU A 377
TRP A 427
 None
GOL  A 507 (-3.2A)
GOL  A 507 (-4.1A)
GOL  A 507 (-3.8A)
GOL  A 507 (-3.5A)
 0.80A 2v3dB-4mdpA:
15.3		 2v3dB-4mdpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 THR A 163
SER A 170
PHE A 140
PHE A 134
TYR A 147
 None
 1.44A 2y00B-4mdpA:
undetectable		 2y00B-4mdpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 THR A 163
SER A 170
PHE A 140
PHE A 134
TYR A 147
 None
 1.46A 2y01B-4mdpA:
undetectable		 2y01B-4mdpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 THR A 163
SER A 170
PHE A 140
PHE A 134
TYR A 147
 None
 1.43A 2y03B-4mdpA:
undetectable		 2y03B-4mdpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 5 LEU A 123
ASP A 128
ILE A  31
GLY A 133
 None
 0.83A 3bufA-4mdpA:
undetectable		 3bufA-4mdpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 GLY A  10
ASN A  71
GLY A 444
LEU A 425
THR A  13
 None
 1.11A 3eeyF-4mdpA:
undetectable		 3eeyF-4mdpA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 ARG A  27
PHE A 134
ALA A 181
ASP A  33
LEU A 173
 None
None
None
None
BGC  A 501 ( 4.9A)
 1.21A 3lcvB-4mdpA:
undetectable		 3lcvB-4mdpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 9 LEU A 360
ILE A 261
ALA A 260
ALA A 238
THR A 239
 None
 1.11A 3mdvA-4mdpA:
undetectable		 3mdvA-4mdpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 7 TYR A 179
LEU A 326
LEU A 173
PHE A 348
 BGC  A 501 ( 4.1A)
None
BGC  A 501 ( 4.9A)
BGC  A 501 (-4.7A)
 1.17A 3nk2X-4mdpA:
undetectable		 3nk2X-4mdpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 GLY A  87
ILE A  83
ASP A 122
LEU A 123
GLU A 139
 None
 0.95A 3o7wA-4mdpA:
undetectable		 3o7wA-4mdpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 LYS A 459
ARG A 399
ASP A 387
 None
 1.32A 3o7wA-4mdpA:
undetectable		 3o7wA-4mdpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 6 ARG A  27
LEU A  85
PRO A  84
SER A  80
 None
 1.31A 3vlnA-4mdpA:
undetectable		 3vlnA-4mdpA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 10 ILE A  31
GLY A 174
TYR A 175
GLU A 199
SER A 191
 None
 1.17A 4bwlC-4mdpA:
10.5		 4bwlC-4mdpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 ASP A 122
TRP A 427
SER A  76
 None
GOL  A 507 (-3.5A)
None
 1.01A 4lrhB-4mdpA:
undetectable		 4lrhB-4mdpA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 12 TYR A 147
ILE A 232
ALA A 148
HIS A 120
ILE A 207
 None
 1.14A 4rvdA-4mdpA:
undetectable		 4rvdA-4mdpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 GLU A 292
ILE A 202
ALA A 210
 None
PEG  A 504 ( 4.4A)
None
 0.63A 4wnwB-4mdpA:
undetectable		 4wnwB-4mdpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 9 ALA A  70
LEU A 430
LEU A  65
LEU A 429
ARG A 456
 None
 1.44A 4x30A-4mdpA:
undetectable		 4x30A-4mdpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 4 PHE A 403
ASP A 396
GLY A 379
SER A 461
 None
 1.35A 4xp9C-4mdpA:
0.0		 4xp9C-4mdpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 6 PHE A 469
GLY A  10
TYR A 424
ALA A 426
 None
 1.30A 4yshB-4mdpA:
undetectable		 4yshB-4mdpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 4 ALA A 294
PRO A 267
LEU A 285
HIS A 205
 None
None
None
PEG  A 504 ( 4.9A)
 1.46A 5eskA-4mdpA:
undetectable		 5eskA-4mdpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 7 GLY A  28
PHE A 134
CYH A  36
ASP A 122
 None
 1.08A 5hieA-4mdpA:
undetectable		 5hieA-4mdpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 8 SER A 381
THR A 441
ARG A 351
PRO A 352
 None
 1.04A 5jhdE-4mdpA:
undetectable
5jhdG-4mdpA:
undetectable		 5jhdE-4mdpA:
18.44
5jhdG-4mdpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 MET A 277
GLN A 280
ARG A 255
 None
 1.14A 5m35B-4mdpA:
undetectable		 5m35B-4mdpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 MET A 277
GLN A 280
ARG A 255
 None
 1.12A 5m36A-4mdpA:
undetectable		 5m36A-4mdpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 8 THR A 380
TYR A 308
THR A 309
ARG A 351
 None
GOL  A 507 (-4.1A)
None
None
 1.15A 5tzoA-4mdpA:
undetectable		 5tzoA-4mdpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 8 THR A 380
TYR A 308
THR A 309
ARG A 351
 None
GOL  A 507 (-4.1A)
None
None
 1.16A 5tzoB-4mdpA:
undetectable		 5tzoB-4mdpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 8 THR A 380
TYR A 308
THR A 309
ARG A 351
 None
GOL  A 507 (-4.1A)
None
None
 1.18A 5tzoC-4mdpA:
undetectable		 5tzoC-4mdpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 4 PHE A 164
LEU A 295
LEU A 208
VAL A 215
 None
 1.20A 5xxiA-4mdpA:
undetectable		 5xxiA-4mdpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 TYR A 273
LEU A 281
ASP A 324
 PO4  A 505 ( 4.9A)
None
None
 0.86A 5zv2B-4mdpA:
undetectable		 5zv2B-4mdpA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		5 / 6 GLY A 194
ASP A 323
GLY A 183
PRO A 182
GLY A 178
 None
 1.42A 6ag0C-4mdpA:
6.4		 6ag0C-4mdpA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 MET A 277
GLN A 280
ARG A 255
 None
 1.11A 6fn9A-4mdpA:
undetectable		 6fn9A-4mdpA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		3 / 3 MET A 277
GLN A 280
ARG A 255
 None
 1.12A 6fnbA-4mdpA:
undetectable		 6fnbA-4mdpA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4mdp BETA-GLUCOSIDASE
(Humicola
grisea) 		4 / 8 ASP A 237
HIS A 307
GLU A 166
GLU A 434
 None
None
GOL  A 507 (-3.2A)
GOL  A 507 (-2.9A)
 1.19A 6mn4C-4mdpA:
undetectable		 6mn4C-4mdpA:
21.27