SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		4 / 8 ASP A 320
CYH A 319
GLY A 371
GLY A 370
 None
 0.82A 1ekjA-4mdrA:
undetectable
1ekjB-4mdrA:
undetectable		 1ekjA-4mdrA:
21.82
1ekjB-4mdrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		4 / 8 ASP A 320
CYH A 319
GLY A 371
GLY A 370
 None
 0.78A 1ekjG-4mdrA:
undetectable
1ekjH-4mdrA:
undetectable		 1ekjG-4mdrA:
21.82
1ekjH-4mdrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		5 / 12 GLY A 277
GLN A 276
LEU A 220
MET A 226
LEU A 272
 None
 1.42A 1p93C-4mdrA:
undetectable		 1p93C-4mdrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		4 / 4 LEU A 315
SER A 301
LEU A 377
LEU A 334
 None
 1.12A 4n09A-4mdrA:
undetectable		 4n09A-4mdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		4 / 5 LEU A 315
SER A 301
LEU A 377
LEU A 334
 None
 1.09A 4n09B-4mdrA:
undetectable		 4n09B-4mdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		4 / 5 LEU A 315
SER A 301
LEU A 377
LEU A 334
 None
 1.11A 4n09D-4mdrA:
undetectable		 4n09D-4mdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 368
GLN A 373
CYH A 319
 None
 0.83A 5icxA-4mdrA:
2.9
5icxE-4mdrA:
undetectable		 5icxA-4mdrA:
22.79
5icxE-4mdrA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.60A 5qgjA-4mdrA:
undetectable		 5qgjA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.66A 5qgmA-4mdrA:
undetectable		 5qgmA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.56A 5qgnA-4mdrA:
undetectable		 5qgnA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.61A 5qgyA-4mdrA:
undetectable		 5qgyA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.62A 5qgzA-4mdrA:
undetectable		 5qgzA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.62A 5qh0A-4mdrA:
undetectable		 5qh0A-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.62A 5qh2A-4mdrA:
undetectable		 5qh2A-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.62A 5qh3A-4mdrA:
undetectable		 5qh3A-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.59A 5qh5A-4mdrA:
undetectable		 5qh5A-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.62A 5qh6A-4mdrA:
undetectable		 5qh6A-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.60A 5qh7A-4mdrA:
undetectable		 5qh7A-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.66A 5qhaA-4mdrA:
undetectable		 5qhaA-4mdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens) 		3 / 3 VAL A 236
VAL A 250
GLN A 285
 None
 0.61A 5qhhA-4mdrA:
undetectable		 5qhhA-4mdrA:
20.00