SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mdv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		5 / 12 MET A 121
LEU A 166
ILE A 134
LEU A 138
TYR A 178
 None
 1.25A 1dreA-4mdvA:
undetectable		 1dreA-4mdvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 6 LEU A 355
LEU A 358
SER A 320
THR A 318
 None
 1.07A 1ictB-4mdvA:
undetectable		 1ictB-4mdvA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		5 / 12 MET A 121
LEU A 166
ILE A 134
LEU A 138
TYR A 178
 None
 1.22A 1rh3A-4mdvA:
undetectable		 1rh3A-4mdvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 ARG A 239
ASN A 243
GLN A 248
ASP A 218
 None
 1.14A 1rs7B-4mdvA:
undetectable		 1rs7B-4mdvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 THR A 354
TYR A 351
LEU A 316
MET A 359
 None
 1.48A 1uw6P-4mdvA:
undetectable
1uw6Q-4mdvA:
undetectable		 1uw6P-4mdvA:
20.94
1uw6Q-4mdvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 6 VAL A 130
LEU A 131
PHE A 135
MET A 170
 None
 1.09A 1x8vA-4mdvA:
undetectable		 1x8vA-4mdvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		5 / 12 LEU A 138
LEU A 166
MET A 170
LEU A 183
THR A 238
 None
 1.23A 2aa6B-4mdvA:
undetectable		 2aa6B-4mdvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 ALA A 188
SER A 165
LEU A 166
VAL A 167
 None
 0.54A 2bxgA-4mdvA:
undetectable		 2bxgA-4mdvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		5 / 12 LEU A 339
ALA A 330
ILE A 327
SER A 292
ARG A 285
 None
 1.25A 3gyqA-4mdvA:
undetectable
3gyqB-4mdvA:
undetectable		 3gyqA-4mdvA:
22.98
3gyqB-4mdvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 ARG A 239
ASN A 243
GLN A 248
ASP A 218
 None
 0.97A 3n62A-4mdvA:
undetectable		 3n62A-4mdvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 ARG A 239
ASN A 243
GLN A 248
ASP A 218
 None
 1.02A 3n62B-4mdvA:
undetectable		 3n62B-4mdvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		3 / 3 ARG A  66
VAL A 101
THR A 354
 None
 0.82A 3ndtA-4mdvA:
undetectable		 3ndtA-4mdvA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 GLU A  43
ASP A  41
SER A  37
ARG A  66
 None
 1.23A 4uhxA-4mdvA:
undetectable		 4uhxA-4mdvA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 8 GLU A  43
ASP A  41
SER A  37
ARG A  66
 None
 1.23A 4uhxA-4mdvA:
undetectable		 4uhxA-4mdvA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 7 LEU A  45
THR A  54
THR A  94
LEU A 102
 None
CA  A 401 ( 4.7A)
None
None
 0.96A 4z91F-4mdvA:
undetectable
4z91G-4mdvA:
undetectable
4z91H-4mdvA:
undetectable
4z91I-4mdvA:
undetectable
4z91J-4mdvA:
undetectable		 4z91F-4mdvA:
21.77
4z91G-4mdvA:
21.77
4z91H-4mdvA:
21.77
4z91I-4mdvA:
21.77
4z91J-4mdvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		5 / 6 PRO A  21
HIS A 212
GLU A 213
ALA A 219
LEU A 222
 None
 1.37A 5igiA-4mdvA:
undetectable		 5igiA-4mdvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		5 / 12 LEU A 339
LEU A 312
SER A 301
ILE A 294
LEU A 113
 None
 1.24A 5ljcA-4mdvA:
undetectable		 5ljcA-4mdvA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 7 SER A 208
ALA A 200
ILE A 195
LEU A  15
 None
 1.05A 5te8A-4mdvA:
undetectable		 5te8A-4mdvA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4mdv ANNEXIN
(Schistosoma
mansoni) 		4 / 6 GLU A 269
ARG A 285
ARG A 277
ASP A 289
 None
 1.27A 5zw4A-4mdvA:
undetectable		 5zw4A-4mdvA:
23.08