SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A  37
GLY A 164
ILE A 163
THR A  46
ILE A  48
 None
 0.80A 1c6yA-4mdyA:
undetectable		 1c6yA-4mdyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 4 VAL A  87
TRP A  79
TRP A  90
 None
PEG  A 401 ( 4.6A)
None
 1.12A 1gmkA-4mdyA:
undetectable
1gmkB-4mdyA:
undetectable		 1gmkA-4mdyA:
7.32
1gmkB-4mdyA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.38A 1ra8A-4mdyA:
undetectable		 1ra8A-4mdyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.00A 1rd7A-4mdyA:
undetectable		 1rd7A-4mdyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 125
VAL A  55
VAL A  69
ASP A  65
VAL A  71
 None
 1.38A 2l8mA-4mdyA:
undetectable		 2l8mA-4mdyA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 248
ALA A 249
ASP A 250
PRO A 216
 None
 0.68A 3el0A-4mdyA:
undetectable		 3el0A-4mdyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 187
LEU A 312
SER A 300
ILE A 253
THR A 285
 None
 1.15A 3frqA-4mdyA:
undetectable		 3frqA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  65
ASP A  64
ASP A 158
ASP A 221
 None
 0.91A 3havA-4mdyA:
undetectable		 3havA-4mdyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.44A 4ej1A-4mdyA:
undetectable		 4ej1A-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.50A 4i13A-4mdyA:
undetectable		 4i13A-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.49A 4kjjA-4mdyA:
undetectable		 4kjjA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.43A 4kjkA-4mdyA:
undetectable		 4kjkA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.45A 4kjlA-4mdyA:
2.1		 4kjlA-4mdyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A  37
GLY A 164
ILE A 163
THR A  46
ILE A  48
 None
 0.85A 4njvB-4mdyA:
undetectable		 4njvB-4mdyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A  37
GLY A 164
ILE A 163
THR A  46
ILE A  48
 None
 0.87A 4njvC-4mdyA:
undetectable		 4njvC-4mdyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.46A 4nx6A-4mdyA:
undetectable		 4nx6A-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.48A 4nx7A-4mdyA:
undetectable		 4nx7A-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		7 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
PRO A 309
ILE A 293
 None
 1.48A 4p3qA-4mdyA:
undetectable		 4p3qA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.49A 4p3rA-4mdyA:
undetectable		 4p3rA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.49A 4pssA-4mdyA:
undetectable		 4pssA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.47A 4pstA-4mdyA:
undetectable		 4pstA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  50
PRO A  51
GLN A  53
 None
 0.53A 4qwpB-4mdyA:
undetectable		 4qwpB-4mdyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.37A 4x5iA-4mdyA:
undetectable		 4x5iA-4mdyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  66
ALA A 166
GLY A  59
ALA A  58
LEU A 103
 None
 1.08A 5jw1B-4mdyA:
undetectable		 5jw1B-4mdyA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 305
ILE A 293
ALA A 292
LEU A 289
 None
 0.76A 5te8B-4mdyA:
undetectable		 5te8B-4mdyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.46A 5z6jA-4mdyA:
undetectable		 5z6jA-4mdyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.46A 5z6kA-4mdyA:
undetectable		 5z6kA-4mdyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4mdy PERIPLASMIC BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 TRP A 156
PHE A 222
THR A 255
ILE A 253
LEU A 308
ILE A 293
 None
 1.45A 7dfrA-4mdyA:
undetectable		 7dfrA-4mdyA:
20.82