SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4me4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		5 / 9 ASP A  99
ILE A 109
ALA A 111
ILE A  72
THR A 106
 None
 1.28A 1aj6A-4me4A:
undetectable		 1aj6A-4me4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		4 / 5 ASP A 222
HIS A 250
HIS A 221
HIS A 276
 FE  A 402 ( 2.5A)
FE  A 401 ( 3.4A)
IMD  A 407 (-3.6A)
FE  A 401 (-3.4A)
 1.05A 1ei6A-4me4A:
undetectable		 1ei6A-4me4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		3 / 3 LEU A 213
HIS A 168
ILE A 172
 None
 0.69A 1s9pB-4me4A:
undetectable		 1s9pB-4me4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		3 / 3 ARG A 107
ARG A 105
ILE A 109
 None
 0.69A 1uobA-4me4A:
undetectable		 1uobA-4me4A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		4 / 4 HIS A 276
ASP A 308
ASN A 188
ASP A 222
 FE  A 401 (-3.4A)
None
None
FE  A 402 ( 2.5A)
 1.35A 1wg8A-4me4A:
undetectable		 1wg8A-4me4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		3 / 3 ARG A 192
SER A 312
TYR A 196
 None
 0.93A 2q2hA-4me4A:
undetectable
2q2hB-4me4A:
undetectable		 2q2hA-4me4A:
19.68
2q2hB-4me4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		4 / 8 LEU A  28
ILE A  43
GLY A 123
ILE A 122
 None
 0.88A 3wxoA-4me4A:
undetectable		 3wxoA-4me4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		5 / 11 THR A 251
GLY A 224
ASP A 222
ARG A 314
GLU A 185
 None
None
FE  A 402 ( 2.5A)
None
IMD  A 407 (-2.4A)
 1.26A 4dx7A-4me4A:
0.0		 4dx7A-4me4A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		3 / 3 GLU A 198
TYR A 173
GLU A 169
 None
 0.81A 4ryaA-4me4A:
undetectable		 4ryaA-4me4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		3 / 3 HIS A 277
HIS A 276
HIS A 250
 FE  A 401 ( 3.3A)
FE  A 401 (-3.4A)
FE  A 401 ( 3.4A)
 0.47A 5zrdA-4me4A:
undetectable		 5zrdA-4me4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4me4 METAL DEPENDENT
PHOSPHOHYDROLASE
(Persephonella
marina) 		3 / 3 ARG A  93
LYS A  70
ARG A 101
 None
 1.30A 6c06D-4me4A:
undetectable		 6c06D-4me4A:
undetectable