SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4me8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.95A 1rxcB-4me8A:
undetectable		 1rxcB-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 7 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.81A 1rxcC-4me8A:
undetectable		 1rxcC-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 7 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.93A 1rxcD-4me8A:
undetectable		 1rxcD-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.95A 1rxcE-4me8A:
undetectable		 1rxcE-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 7 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 1.02A 1rxcF-4me8A:
undetectable		 1rxcF-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.98A 1rxcI-4me8A:
undetectable		 1rxcI-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.94A 1rxcK-4me8A:
undetectable		 1rxcK-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 7 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.99A 1rxcL-4me8A:
undetectable		 1rxcL-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		5 / 10 ARG A 151
THR A 116
TYR A 101
GLU A  99
TYR A  85
 None
 1.49A 1v3eA-4me8A:
undetectable		 1v3eA-4me8A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		5 / 12 ASP A 142
GLY A 141
ASP A 149
PHE A 119
VAL A  83
 EDO  A 200 (-3.9A)
EDO  A 200 (-3.4A)
None
None
None
 1.28A 2fqyA-4me8A:
undetectable		 2fqyA-4me8A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		5 / 10 ARG A  86
THR A  89
VAL A  83
GLU A  84
ILE A  76
 None
 1.43A 3uayA-4me8A:
undetectable		 3uayA-4me8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.98A 4e1vA-4me8A:
undetectable		 4e1vA-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 7 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.91A 4e1vB-4me8A:
undetectable		 4e1vB-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.95A 4e1vC-4me8A:
undetectable		 4e1vC-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.94A 4e1vD-4me8A:
undetectable		 4e1vD-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.94A 4e1vE-4me8A:
undetectable		 4e1vE-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.97A 4e1vG-4me8A:
undetectable		 4e1vG-4me8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4me8 SIGNAL PEPTIDASE I
(Enterococcus
faecalis) 		4 / 8 GLY A 163
ILE A  60
VAL A 164
PRO A  54
 None
 0.93A 4e1vH-4me8A:
undetectable		 4e1vH-4me8A:
23.53