SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 12 SER A 104
VAL A 101
PHE A 348
PHE A  87
MET A 181
 None
 1.46A 1fdsA-4meaA:
4.5		 1fdsA-4meaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 SER A 342
VAL A 339
GLY A 338
GLU A 333
 None
 0.91A 1fduD-4meaA:
4.8		 1fduD-4meaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 12 TYR A 235
GLY A  92
PHE A 228
TYR A 267
PHE A 264
 None
 1.46A 1maaC-4meaA:
11.9		 1maaC-4meaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 TYR A 193
HIS A 206
GLU A 307
VAL A 300
 None
 1.43A 1q13A-4meaA:
undetectable		 1q13A-4meaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		6 / 11 GLY A 148
ALA A 147
ILE A  66
GLY A 141
ILE A 140
ILE A 112
 None
 1.32A 1sdvB-4meaA:
undetectable		 1sdvB-4meaA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 LEU A 159
ALA A 263
LEU A 116
SER A 122
 None
 1.05A 1tz8C-4meaA:
undetectable
1tz8D-4meaA:
undetectable		 1tz8C-4meaA:
19.01
1tz8D-4meaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 5 TRP A  95
LEU A 119
GLY A 118
LYS A 259
 None
 1.13A 1ya4C-4meaA:
12.2		 1ya4C-4meaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 9 ILE A  66
GLY A 141
ILE A 140
PRO A 117
ILE A 114
 None
 1.10A 2avoA-4meaA:
undetectable		 2avoA-4meaA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		6 / 12 GLY A 148
ALA A 147
ILE A  66
GLY A 141
ILE A 140
ILE A 112
 None
 1.31A 2r5pD-4meaA:
undetectable		 2r5pD-4meaA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 8 TYR A 235
SER A 183
TYR A 193
HIS A 206
 None
 1.39A 2v0gA-4meaA:
undetectable		 2v0gA-4meaA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		3 / 3 SER A  32
THR A 234
PHE A  91
 None
 0.60A 2x91A-4meaA:
undetectable		 2x91A-4meaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		3 / 3 GLY A 237
GLY A 299
GLY A 328
 None
 0.34A 3bogC-4meaA:
undetectable		 3bogC-4meaA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		3 / 3 GLY A 237
GLY A 299
GLY A 328
 None
 0.19A 3bogD-4meaA:
undetectable		 3bogD-4meaA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 10 GLY A 148
ALA A 147
VAL A  86
GLY A 141
ILE A 152
 None
 0.85A 3ekpD-4meaA:
undetectable		 3ekpD-4meaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 11 GLY A 148
ALA A 147
VAL A  86
GLY A 141
ILE A 152
 None
 0.85A 3ektC-4meaA:
undetectable		 3ektC-4meaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		3 / 3 ASN A 283
ASN A 170
GLU A 133
 None
 0.85A 3kpdC-4meaA:
undetectable		 3kpdC-4meaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		3 / 3 ASN A 283
ASN A 170
GLU A 133
 None
 0.92A 3kpdB-4meaA:
undetectable		 3kpdB-4meaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 5 ASP A 158
LEU A 159
ILE A 185
PRO A 184
 None
 1.19A 3s3vA-4meaA:
undetectable		 3s3vA-4meaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 4 LEU A 116
GLY A  90
GLY A 160
THR A 162
 None
 0.97A 3si7A-4meaA:
undetectable		 3si7A-4meaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 5 PHE A  87
TYR A 153
ILE A  66
LEU A  73
 None
 0.86A 3sueC-4meaA:
undetectable		 3sueC-4meaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 9 ILE A  66
GLY A 141
ILE A 140
PRO A 117
LEU A 116
 None
 1.19A 3u7sB-4meaA:
undetectable		 3u7sB-4meaA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 12 LEU A 347
PHE A 346
LEU A 343
ILE A 289
VAL A 332
 None
 1.40A 3w1wB-4meaA:
2.6		 3w1wB-4meaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 7 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.85A 4eq4A-4meaA:
undetectable		 4eq4A-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 8 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.82A 4eq4B-4meaA:
undetectable		 4eq4B-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 7 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.84A 4eqlA-4meaA:
undetectable		 4eqlA-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 7 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.85A 4eqlB-4meaA:
undetectable		 4eqlB-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 12 ASP A 158
PHE A 210
TYR A 267
HIS A 329
TRP A 330
 None
 0.49A 4j03A-4meaA:
29.2		 4j03A-4meaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.88A 4l39A-4meaA:
undetectable		 4l39A-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 7 LEU A 167
TYR A 154
ILE A 114
GLY A 141
 None
 0.88A 4l39B-4meaA:
undetectable		 4l39B-4meaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 10 GLY A 148
ALA A 147
VAL A  86
GLY A 141
ILE A 152
 None
 0.83A 4ll3B-4meaA:
undetectable		 4ll3B-4meaA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 10 GLY A 148
ALA A 147
VAL A  86
GLY A 141
ILE A 152
 None
 0.83A 4ll3A-4meaA:
undetectable		 4ll3A-4meaA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 TYR A 267
TYR A 254
LEU A 260
PHE A 228
 None
 1.31A 4twdB-4meaA:
undetectable
4twdC-4meaA:
undetectable		 4twdB-4meaA:
23.53
4twdC-4meaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 TYR A 267
TYR A 254
LEU A 260
PHE A 228
 None
 1.29A 4twdD-4meaA:
undetectable
4twdE-4meaA:
undetectable		 4twdD-4meaA:
23.53
4twdE-4meaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		4 / 6 TYR A 267
TYR A 254
LEU A 260
PHE A 228
 None
 1.39A 4twdF-4meaA:
undetectable
4twdG-4meaA:
undetectable		 4twdF-4meaA:
23.53
4twdG-4meaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4mea PREDICTED PROTEIN
(Acinetobacter
nosocomialis) 		5 / 10 SER A 122
ILE A 146
ALA A 142
LEU A 139
PHE A 346
 None
 1.39A 5zjiA-4meaA:
undetectable
5zjiJ-4meaA:
undetectable		 5zjiA-4meaA:
13.08
5zjiJ-4meaA:
8.62