SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		5 / 10 GLN A 145
PHE A 167
GLY A 144
GLY A 161
MET A  51
 None
 1.49A 2y6rA-4mecA:
undetectable		 2y6rA-4mecA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		5 / 8 GLN A 145
PHE A 167
GLY A 144
GLY A 161
MET A  51
 None
 1.49A 2y6rB-4mecA:
undetectable		 2y6rB-4mecA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		5 / 12 GLN A 145
PHE A 167
GLY A 144
GLY A 161
MET A  51
 None
 1.50A 2y6rC-4mecA:
undetectable		 2y6rC-4mecA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 6 HIS A 132
THR A 135
LEU A 118
LEU A  61
 None
ZNH  A 300 (-4.7A)
None
None
 1.10A 3bgdA-4mecA:
undetectable		 3bgdA-4mecA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		5 / 11 ALA A 206
LEU A 118
VAL A 121
ILE A  65
THR A 205
 None
 1.29A 3jw5A-4mecA:
undetectable		 3jw5A-4mecA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 133
LEU A  77
ASP A 140
TYR A 182
 None
 1.04A 3qj7A-4mecA:
undetectable
3qj7D-4mecA:
undetectable		 3qj7A-4mecA:
22.89
3qj7D-4mecA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 MET A  93
TRP A 101
GLU A  62
ARG A  85
 None
 1.49A 4r87J-4mecA:
undetectable
4r87L-4mecA:
undetectable		 4r87J-4mecA:
21.28
4r87L-4mecA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 MET A  34
PHE A  33
SER A  31
LEU A 217
 ZNH  A 300 ( 4.3A)
None
None
None
 1.10A 4xk8A-4mecA:
undetectable		 4xk8A-4mecA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 6 PHE A  47
SER A  53
ALA A  52
LEU A  49
 None
 1.19A 5dzkB-4mecA:
undetectable
5dzkP-4mecA:
undetectable		 5dzkB-4mecA:
25.29
5dzkP-4mecA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 PHE A  47
SER A  53
ALA A  52
LEU A  49
 None
 1.06A 5dzkD-4mecA:
undetectable
5dzkR-4mecA:
undetectable		 5dzkD-4mecA:
25.29
5dzkR-4mecA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4mec HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 4 LEU A 181
MET A 186
ILE A 172
LEU A 138
 None
None
None
ZNH  A 300 ( 4.4A)
 1.23A 5nfpA-4mecA:
undetectable		 5nfpA-4mecA:
20.69