SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 11 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.94A 1c6yA-4mesA:
undetectable		 1c6yA-4mesA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		4 / 7 LEU A  10
LEU A  53
GLY A  52
LEU A  47
 PG4  A 211 (-4.4A)
None
None
None
 0.94A 1gtiA-4mesA:
undetectable		 1gtiA-4mesA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 10 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.99A 1hsgA-4mesA:
undetectable		 1hsgA-4mesA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 11 LEU A 166
ALA A  95
LEU A  92
THR A 114
VAL A 110
 None
 1.14A 1ictA-4mesA:
undetectable
1ictC-4mesA:
undetectable		 1ictA-4mesA:
17.42
1ictC-4mesA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		6 / 11 GLY A  59
GLY A  56
ILE A  24
LEU A  20
ALA A  18
ALA A  21
 None
None
P6G  A 220 (-4.0A)
P6G  A 220 (-4.9A)
None
None
 1.48A 1x7pA-4mesA:
undetectable
1x7pB-4mesA:
undetectable		 1x7pA-4mesA:
20.91
1x7pB-4mesA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		6 / 11 GLY A  60
GLY A  56
ILE A  24
LEU A  20
ALA A  18
ALA A  21
 None
None
P6G  A 220 (-4.0A)
P6G  A 220 (-4.9A)
None
None
 1.30A 1x7pA-4mesA:
undetectable
1x7pB-4mesA:
undetectable		 1x7pA-4mesA:
20.91
1x7pB-4mesA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  10
GLY A  59
GLY A  56
LEU A  53
GLY A  96
 PG4  A 211 (-4.4A)
None
None
None
None
 1.03A 1y4lA-4mesA:
undetectable		 1y4lA-4mesA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.95A 2o4lA-4mesA:
undetectable		 2o4lA-4mesA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		4 / 6 ALA A  95
LEU A  92
THR A 114
VAL A 110
 None
 1.01A 3d2tB-4mesA:
undetectable		 3d2tB-4mesA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.88A 3k4vD-4mesA:
undetectable		 3k4vD-4mesA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 GLY A  59
GLY A  56
LEU A  61
LEU A  92
ALA A  18
 None
None
PEG  A 212 ( 3.7A)
None
None
 1.16A 3kkzA-4mesA:
undetectable		 3kkzA-4mesA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.87A 3nduA-4mesA:
undetectable		 3nduA-4mesA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.91A 3nduD-4mesA:
undetectable		 3nduD-4mesA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		4 / 8 GLU A  38
LEU A  92
ALA A  40
ALA A  21
 26G  A 203 (-3.8A)
None
None
None
 0.98A 3ns1L-4mesA:
undetectable		 3ns1L-4mesA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 11 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 1.01A 3oxxD-4mesA:
undetectable		 3oxxD-4mesA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.94A 3pwrA-4mesA:
undetectable		 3pwrA-4mesA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_A_VIBA191_1
(THIT)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		9 / 10 GLU A  38
GLU A  84
TYR A  85
HIS A 125
GLY A 129
TRP A 133
TYR A 146
VAL A 150
ASN A 151
 26G  A 203 (-3.8A)
26G  A 203 (-2.9A)
26G  A 203 (-4.6A)
26G  A 203 (-3.4A)
26G  A 203 (-3.3A)
26G  A 203 (-3.3A)
26G  A 203 (-4.2A)
26G  A 203 ( 4.5A)
26G  A 203 (-3.3A)
 0.16A 3rlbA-4mesA:
34.1		 3rlbA-4mesA:
94.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_A_VIBA191_1
(THIT)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		6 / 10 TRP A  34
GLY A 129
TRP A 133
TYR A 146
VAL A 150
ASN A 151
 PG4  A 210 (-3.9A)
26G  A 203 (-3.3A)
26G  A 203 (-3.3A)
26G  A 203 (-4.2A)
26G  A 203 ( 4.5A)
26G  A 203 (-3.3A)
 1.01A 3rlbA-4mesA:
34.1		 3rlbA-4mesA:
94.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_B_VIBB187_1
(THIT)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 ILE A  36
GLU A  38
GLU A  84
HIS A 125
TYR A 136
 PG4  A 210 (-4.3A)
26G  A 203 (-3.8A)
26G  A 203 (-2.9A)
26G  A 203 (-3.4A)
None
 1.36A 3rlbB-4mesA:
34.4		 3rlbB-4mesA:
94.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_B_VIBB187_1
(THIT)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		11 / 12 ILE A  36
GLU A  38
GLU A  84
TYR A  85
TYR A 122
HIS A 125
GLY A 129
TRP A 133
TYR A 146
VAL A 150
ASN A 151
 PG4  A 210 (-4.3A)
26G  A 203 (-3.8A)
26G  A 203 (-2.9A)
26G  A 203 (-4.6A)
None
26G  A 203 (-3.4A)
26G  A 203 (-3.3A)
26G  A 203 (-3.3A)
26G  A 203 (-4.2A)
26G  A 203 ( 4.5A)
26G  A 203 (-3.3A)
 0.15A 3rlbB-4mesA:
34.4		 3rlbB-4mesA:
94.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_B_VIBB187_1
(THIT)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		6 / 12 TRP A  34
GLY A 129
TRP A 133
TYR A 146
VAL A 150
ASN A 151
 PG4  A 210 (-3.9A)
26G  A 203 (-3.3A)
26G  A 203 (-3.3A)
26G  A 203 (-4.2A)
26G  A 203 ( 4.5A)
26G  A 203 (-3.3A)
 0.99A 3rlbB-4mesA:
34.4		 3rlbB-4mesA:
94.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.94A 3tkgA-4mesA:
undetectable		 3tkgA-4mesA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 11 PHE A 124
GLY A  56
LEU A  57
LEU A  45
ALA A 117
 None
None
PEG  A 212 ( 4.5A)
None
None
 1.13A 4wnuA-4mesA:
undetectable		 4wnuA-4mesA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 GLY A  59
GLY A  56
GLY A  93
LEU A  92
ALA A  19
 None
None
None
None
BNG  A 201 ( 3.7A)
 0.97A 5c0oF-4mesA:
undetectable		 5c0oF-4mesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 ALA A  95
LEU A 166
LEU A  45
ILE A  42
SER A  91
 None
None
None
P6G  A 220 (-3.9A)
PG4  A 207 (-4.8A)
 1.41A 5uanB-4mesA:
undetectable		 5uanB-4mesA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 ALA A  95
LEU A 166
LEU A  45
ILE A  44
SER A  91
 None
None
None
None
PG4  A 207 (-4.8A)
 1.29A 5uanB-4mesA:
undetectable		 5uanB-4mesA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.90A 6dh6A-4mesA:
undetectable		 6dh6A-4mesA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 4mes THIAMINE TRANSPORTER
THIT
(Lactococcus
lactis) 		5 / 12 LEU A  45
ALA A  21
ILE A  62
GLY A  64
ILE A  44
 None
 0.98A 6difA-4mesA:
undetectable		 6difA-4mesA:
21.80