SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		4 / 7 VAL A 318
ILE A 319
GLU A 384
LEU A 339
 None
 1.08A 1j96B-4mewA:
undetectable		 1j96B-4mewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		4 / 8 SER A 289
ILE A 266
PHE A 234
VAL A 218
 None
 1.17A 1kb9A-4mewA:
undetectable
1kb9C-4mewA:
undetectable
1kb9D-4mewA:
undetectable
1kb9E-4mewA:
undetectable		 1kb9A-4mewA:
21.90
1kb9C-4mewA:
21.80
1kb9D-4mewA:
20.99
1kb9E-4mewA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 12 PHE A 434
PHE A 471
PHE A 397
LEU A 458
VAL A 445
 None
 1.34A 1q23C-4mewA:
undetectable		 1q23C-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 12 PHE A 434
PHE A 471
PHE A 397
LEU A 458
VAL A 445
 None
 1.45A 1q23D-4mewA:
undetectable
1q23E-4mewA:
undetectable		 1q23D-4mewA:
20.11
1q23E-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 11 PHE A 270
PHE A 291
LEU A 298
VAL A 241
PHE A 237
 None
 1.36A 1q23G-4mewA:
undetectable		 1q23G-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 11 PHE A 434
PHE A 471
PHE A 397
LEU A 458
VAL A 445
 None
 1.43A 1q23G-4mewA:
undetectable		 1q23G-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 12 PRO A 236
GLY A 185
PHE A 199
ILE A 206
LEU A 220
 None
 1.17A 3iv6C-4mewA:
undetectable		 3iv6C-4mewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 12 SER A 383
PHE A 380
ILE A 355
CYH A 399
PHE A 397
 None
 1.23A 3ko0G-4mewA:
5.2
3ko0H-4mewA:
3.0
3ko0I-4mewA:
4.3
3ko0J-4mewA:
2.8		 3ko0G-4mewA:
12.64
3ko0H-4mewA:
12.64
3ko0I-4mewA:
12.64
3ko0J-4mewA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 11 SER A 383
PHE A 380
ILE A 355
CYH A 399
PHE A 397
 None
 1.29A 3ko0O-4mewA:
2.9
3ko0P-4mewA:
2.9
3ko0Q-4mewA:
3.2
3ko0R-4mewA:
4.6		 3ko0O-4mewA:
12.64
3ko0P-4mewA:
12.64
3ko0Q-4mewA:
12.64
3ko0R-4mewA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 11 SER A 383
PHE A 380
ILE A 355
CYH A 399
PHE A 397
 None
 1.30A 3ko0Q-4mewA:
3.2
3ko0R-4mewA:
4.5
3ko0S-4mewA:
4.4
3ko0T-4mewA:
4.2		 3ko0Q-4mewA:
12.64
3ko0R-4mewA:
12.64
3ko0S-4mewA:
12.64
3ko0T-4mewA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 9 PHE A 234
VAL A 273
LEU A 229
THR A 282
ILE A 281
 None
 1.21A 3tbgD-4mewA:
undetectable		 3tbgD-4mewA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		5 / 12 PHE A 237
PHE A 311
LEU A 286
VAL A 218
VAL A 273
 None
 1.06A 3u9fP-4mewA:
undetectable
3u9fS-4mewA:
undetectable		 3u9fP-4mewA:
20.11
3u9fS-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA
(Homo
sapiens) 		4 / 5 LEU A 238
LEU A 248
PHE A 237
LEU A 298
 None
 0.91A 5gtrA-4mewA:
undetectable		 5gtrA-4mewA:
21.31