SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A  84
ALA A  88
ALA A  93
VAL A  57
LEU A   8
 None
 0.91A 1cbrA-4mf4A:
undetectable		 1cbrA-4mf4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A  84
ALA A  88
ALA A  93
VAL A  57
LEU A   8
 None
 0.91A 1cbrB-4mf4A:
undetectable		 1cbrB-4mf4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A  96
GLY A  92
PRO A  78
VAL A  77
VAL A  75
 None
 0.81A 2nnkA-4mf4A:
undetectable		 2nnkA-4mf4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A  96
GLY A  92
PRO A  78
VAL A  77
VAL A  75
 None
 0.86A 2nnkB-4mf4A:
undetectable		 2nnkB-4mf4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A  96
GLY A  92
ILE A  45
VAL A  77
VAL A  75
 None
 0.93A 3ucbA-4mf4A:
undetectable		 3ucbA-4mf4A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		3 / 3 ARG A 126
PHE A 116
PRO A 117
 None
 0.72A 3zoaB-4mf4A:
4.2		 3zoaB-4mf4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		3 / 3 GLY A 223
SER A 242
TRP A 247
 None
 0.98A 4e7cD-4mf4A:
undetectable		 4e7cD-4mf4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 PHE A 116
GLY A 124
SER A 121
VAL A 111
LEU A 113
 None
 1.10A 5kocA-4mf4A:
undetectable		 5kocA-4mf4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		4 / 4 PHE A  98
LEU A  61
LEU A  89
VAL A  74
 None
 1.33A 5xxiA-4mf4A:
undetectable		 5xxiA-4mf4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 10 MET A 204
SER A 159
LEU A 185
ASP A 184
ILE A 169
 None
None
None
EDO  A 301 (-4.0A)
None
 1.48A 6dlzB-4mf4A:
undetectable
6dlzC-4mf4A:
undetectable		 6dlzB-4mf4A:
14.45
6dlzC-4mf4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 10 MET A 204
SER A 159
LEU A 185
ASP A 184
ILE A 169
 None
None
None
EDO  A 301 (-4.0A)
None
 1.48A 6dm1B-4mf4A:
undetectable
6dm1C-4mf4A:
undetectable		 6dm1B-4mf4A:
14.45
6dm1C-4mf4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 10 MET A 204
SER A 159
LEU A 185
ASP A 184
ILE A 169
 None
None
None
EDO  A 301 (-4.0A)
None
 1.47A 6dm2B-4mf4A:
2.0
6dm2C-4mf4A:
undetectable		 6dm2B-4mf4A:
14.45
6dm2C-4mf4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN
(Burkholderia
cenocepacia) 		5 / 10 ILE A 169
MET A 204
SER A 159
LEU A 185
ASP A 184
 None
None
None
None
EDO  A 301 (-4.0A)
 1.47A 6dm2A-4mf4A:
2.0
6dm2D-4mf4A:
undetectable		 6dm2A-4mf4A:
14.45
6dm2D-4mf4A:
14.45