SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 VAL A 203
TYR A 197
GLY A 200
TRP A 189
 None
BEZ  A 303 (-4.2A)
None
GSH  A 302 (-4.4A)
 1.00A 1lweA-4mf6A:
undetectable		 1lweA-4mf6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		5 / 12 LEU A 161
ILE A 126
ILE A 205
VAL A 219
VAL A 224
 None
 1.08A 2ygnA-4mf6A:
undetectable		 2ygnA-4mf6A:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
 GSH  A 301 (-3.3A)
GSH  A 302 ( 4.4A)
BEZ  A 303 (-3.4A)
BEZ  A 303 (-3.5A)
BEZ  A 303 (-4.2A)
 0.00A 4mf6A-4mf6A:
42.3		 4mf6A-4mf6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 0.78A 4z4fA-4mf6A:
undetectable		 4z4fA-4mf6A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 0.85A 5t7bA-4mf6A:
undetectable		 5t7bA-4mf6A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		5 / 10 ILE A 126
PHE A 208
LEU A 164
ALA A 214
GLU A  40
 None
 1.21A 5y7pG-4mf6A:
undetectable		 5y7pG-4mf6A:
22.22