SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mf9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_A_DVAA8_0
(GRAMICIDIN D)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 305
TRP A 344
VAL A 314
TRP A 317
 None
None
HEM  A 400 ( 4.9A)
None
 1.47A 1al4A-4mf9A:
undetectable
1al4B-4mf9A:
undetectable		 1al4A-4mf9A:
4.30
1al4B-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALZ_A_DVAA8_0
(ILE-GRAMICIDIN C
VAL-GRAMICIDIN A)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 305
TRP A 344
VAL A 314
TRP A 317
 None
None
HEM  A 400 ( 4.9A)
None
 1.41A 1alzA-4mf9A:
undetectable
1alzB-4mf9A:
undetectable		 1alzA-4mf9A:
3.55
1alzB-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.59A 1av2C-4mf9A:
undetectable
1av2D-4mf9A:
undetectable		 1av2C-4mf9A:
4.30
1av2D-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  42
VAL A 144
ASP A 140
ALA A 174
SER A  47
 None
 1.09A 1kiaD-4mf9A:
undetectable		 1kiaD-4mf9A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  42
VAL A 144
ASP A 140
ALA A 174
SER A  47
 None
 1.11A 1nbhC-4mf9A:
undetectable		 1nbhC-4mf9A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  42
VAL A 144
ASP A 140
ALA A 174
SER A  47
 None
 1.13A 1nbiA-4mf9A:
undetectable		 1nbiA-4mf9A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  42
VAL A 144
ASP A 140
ALA A 174
SER A  47
 None
 1.11A 1nbiB-4mf9A:
undetectable		 1nbiB-4mf9A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  90
ALA A 125
ILE A 124
VAL A 164
LEU A  63
 None
 1.32A 1udtA-4mf9A:
undetectable		 1udtA-4mf9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.57A 1w5uC-4mf9A:
undetectable
1w5uD-4mf9A:
undetectable		 1w5uC-4mf9A:
4.30
1w5uD-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 314
TRP A 202
VAL A 305
 HEM  A 400 ( 4.9A)
None
None
 0.56A 2izqA-4mf9A:
undetectable
2izqB-4mf9A:
undetectable		 2izqA-4mf9A:
4.30
2izqB-4mf9A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 267
LEU A 111
LEU A  67
GLY A  68
 None
 0.80A 2qqcD-4mf9A:
undetectable
2qqcE-4mf9A:
undetectable		 2qqcD-4mf9A:
13.54
2qqcE-4mf9A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 182
PRO A  58
GLY A 116
TRP A  60
 None
 1.40A 3aqiA-4mf9A:
undetectable		 3aqiA-4mf9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 291
HIS A  84
VAL A 258
 None
 0.81A 3elzB-4mf9A:
undetectable		 3elzB-4mf9A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.61A 3l8lA-4mf9A:
undetectable
3l8lB-4mf9A:
undetectable		 3l8lA-4mf9A:
4.30
3l8lB-4mf9A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.57A 3l8lC-4mf9A:
undetectable
3l8lD-4mf9A:
undetectable		 3l8lC-4mf9A:
4.30
3l8lD-4mf9A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 220
LEU A 214
LEU A 215
GLY A 201
ALA A 197
 None
 1.25A 3lbdA-4mf9A:
undetectable		 3lbdA-4mf9A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 331
GLN A 329
VAL A 305
HIS A 212
TRP A 202
 HEM  A 400 (-4.3A)
HEM  A 400 (-3.7A)
None
None
None
 1.07A 3lxeA-4mf9A:
undetectable		 3lxeA-4mf9A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 331
GLN A 329
VAL A 305
HIS A 212
TRP A 202
 HEM  A 400 (-4.3A)
HEM  A 400 (-3.7A)
None
None
None
 1.05A 3lxeB-4mf9A:
undetectable		 3lxeB-4mf9A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  56
ALA A  66
ILE A  73
VAL A 121
LEU A  63
 None
 1.00A 3ogpA-4mf9A:
undetectable		 3ogpA-4mf9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		6 / 12 ILE A 268
LEU A 113
GLY A 102
THR A  94
VAL A 105
ASP A 110
 None
 1.12A 4c9lA-4mf9A:
undetectable		 4c9lA-4mf9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		6 / 12 ILE A 268
LEU A 113
GLY A 102
THR A  94
VAL A 105
ASP A 110
 None
 1.13A 4c9lB-4mf9A:
undetectable		 4c9lB-4mf9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 268
LEU A 113
GLY A 102
THR A  94
ASP A 110
 None
 1.00A 4c9oB-4mf9A:
undetectable		 4c9oB-4mf9A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 5 GLY A  68
LEU A 113
ILE A 109
LEU A 167
 None
 0.88A 4o8fA-4mf9A:
undetectable		 4o8fA-4mf9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 123
ARG A 168
ALA A 125
GLU A 161
 None
 1.27A 5a06C-4mf9A:
undetectable
5a06D-4mf9A:
undetectable		 5a06C-4mf9A:
21.52
5a06D-4mf9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  32
TRP A  18
ALA A  30
LEU A  44
 None
 1.05A 5nwvA-4mf9A:
undetectable		 5nwvA-4mf9A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4mf9 HEMIN DEGRADING
FACTOR
(Pseudomonas
aeruginosa) 		4 / 6 TRP A  18
GLY A 143
ALA A  34
LEU A  44
 None
 1.06A 6fosA-4mf9A:
undetectable		 6fosA-4mf9A:
14.12