SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 11 SER A 319
ASN A 326
LEU A 270
ALA A 267
LEU A 266
 None
 1.43A 1hwkC-4mfvA:
undetectable		 1hwkC-4mfvA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 410
ILE A 382
GLY A 378
ILE A 376
ALA A 360
 None
 0.89A 1sguB-4mfvA:
undetectable		 1sguB-4mfvA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A 410
ILE A 382
GLY A 378
ILE A 376
ALA A 360
 None
 0.97A 1sh9B-4mfvA:
undetectable		 1sh9B-4mfvA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 383
GLY A 378
LEU A 357
LEU A 336
LEU A 411
 None
 0.99A 1ya4C-4mfvA:
undetectable		 1ya4C-4mfvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 386
LEU A 441
LEU A 415
LEU A 426
 None
 0.99A 2bfpD-4mfvA:
undetectable		 2bfpD-4mfvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A 558
LEU A 559
LEU A 557
ILE A 533
TYR A 498
 None
 1.11A 2f8dA-4mfvA:
undetectable		 2f8dA-4mfvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 557
GLY A 558
LEU A 559
LEU A 560
TYR A 498
 None
 1.10A 2f8dA-4mfvA:
undetectable		 2f8dA-4mfvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 117
LEU A 150
GLY A 151
VAL A 161
ALA A 160
 None
 1.20A 2kceB-4mfvA:
undetectable		 2kceB-4mfvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 451
ARG A 440
ILE A 496
LEU A 490
VAL A 492
 None
 1.16A 4azwA-4mfvA:
undetectable		 4azwA-4mfvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A 286
CYH A 320
LEU A 280
GLY A 285
 None
 0.79A 5a06B-4mfvA:
undetectable		 5a06B-4mfvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 141
GLN A 144
LEU A 146
LEU A 147
LEU A 149
 None
 1.03A 5nwwA-4mfvA:
undetectable		 5nwwA-4mfvA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4mfv BETA-CATENIN-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 387
PHE A 383
ILE A 382
LEU A 379
ILE A 503
 None
 1.00A 6fgcA-4mfvA:
undetectable		 6fgcA-4mfvA:
9.74