SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 6 LEU A 183
GLY A  87
LYS A  90
TYR A  89
 None
 1.26A 1gtiC-4mfzA:
undetectable		 1gtiC-4mfzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 5 LEU A 183
GLY A  87
LYS A  90
TYR A  89
 None
 1.26A 1gtiF-4mfzA:
undetectable		 1gtiF-4mfzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		3 / 3 ARG A  42
THR A  62
VAL A  59
 None
 0.87A 1hxbA-4mfzA:
undetectable		 1hxbA-4mfzA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 10 ALA A 232
LEU A 318
PRO A 319
PHE A 220
GLY A 228
 None
 1.32A 1mjqG-4mfzA:
undetectable
1mjqH-4mfzA:
undetectable		 1mjqG-4mfzA:
17.21
1mjqH-4mfzA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		3 / 3 ASP A 271
HIS A 302
ASP A 240
 None
 0.74A 1nw5A-4mfzA:
undetectable		 1nw5A-4mfzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 11 LEU A 183
TYR A 174
GLY A 228
HIS A 126
LEU A 122
 None
 1.04A 1p91A-4mfzA:
undetectable		 1p91A-4mfzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 7 ASN A 282
TYR A 281
LEU A 289
GLN A 284
 None
 1.01A 1qzrA-4mfzA:
undetectable		 1qzrA-4mfzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 7 ASN A 282
TYR A 281
LEU A 289
GLN A 284
 None
 0.91A 1qzrB-4mfzA:
undetectable		 1qzrB-4mfzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 10 ASP A 271
GLN A 242
SER A 251
TYR A 246
LEU A 295
 None
None
MFK  A 401 (-2.6A)
None
MFK  A 401 (-3.8A)
 1.40A 1zp4C-4mfzA:
0.0		 1zp4C-4mfzA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 9 LEU A  99
PHE A 110
LEU A  12
LEU A  20
ALA A  70
 None
 1.19A 2bxeA-4mfzA:
undetectable		 2bxeA-4mfzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 LEU A  99
PHE A 110
LEU A  12
LEU A  20
ALA A  70
 None
 1.18A 2bxpA-4mfzA:
undetectable		 2bxpA-4mfzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		3 / 3 ARG A  42
THR A  62
VAL A  59
 None
 0.67A 2q64A-4mfzA:
undetectable		 2q64A-4mfzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		3 / 3 ARG A  42
THR A  62
VAL A  59
 None
 0.80A 2qakA-4mfzA:
undetectable		 2qakA-4mfzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1A-4mfzA:
undetectable		 3ln1A-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1B-4mfzA:
undetectable		 3ln1B-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.83A 3ln1C-4mfzA:
undetectable		 3ln1C-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1D-4mfzA:
0.9		 3ln1D-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 LEU A 213
THR A 233
ILE A 316
ALA A 231
ALA A 216
 None
 0.97A 3mdvB-4mfzA:
undetectable		 3mdvB-4mfzA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		3 / 3 ARG A 123
LEU A 122
THR A 128
 None
 0.89A 3oxcA-4mfzA:
undetectable		 3oxcA-4mfzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 7 LEU A  71
ALA A  61
ASP A  68
TYR A 113
 None
 1.17A 3rodD-4mfzA:
undetectable		 3rodD-4mfzA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 5 SER A 146
ILE A  58
GLY A 144
PRO A  51
 None
 1.03A 3uboB-4mfzA:
undetectable		 3uboB-4mfzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 4 ASN A 182
ALA A 184
GLY A 194
THR A 233
 None
 0.94A 4bboC-4mfzA:
undetectable		 4bboC-4mfzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 7 PHE A 224
GLY A 171
ILE A 131
PHE A 219
 None
 0.88A 4ejjA-4mfzA:
undetectable		 4ejjA-4mfzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 ALA A 232
ARG A 215
ILE A 197
PRO A 198
LEU A 204
 None
None
MFK  A 401 (-4.0A)
None
MFK  A 401 (-4.6A)
 0.89A 4m6kA-4mfzA:
undetectable		 4m6kA-4mfzA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MFP_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 5 GLN A 142
MET A 161
TRP A 163
TRP A 164
 None
 1.18A 4mfpA-4mfzA:
43.5		 4mfpA-4mfzA:
72.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 LEU A 172
GLY A 171
LEU A 122
VAL A  83
THR A 128
 None
 1.44A 4ojbA-4mfzA:
undetectable		 4ojbA-4mfzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 LEU A 172
GLY A 171
LEU A 122
VAL A  83
THR A 128
 None
 1.34A 4olmA-4mfzA:
undetectable		 4olmA-4mfzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 LEU A 122
GLU A 133
THR A 139
PHE A 219
GLY A 177
 None
 1.35A 4q15B-4mfzA:
undetectable		 4q15B-4mfzA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q36_A_GCSA404_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 5 MET A 161
TRP A 163
TRP A 164
PHE A 277
 None
None
None
MFK  A 401 (-4.5A)
 1.12A 4q36A-4mfzA:
43.5		 4q36A-4mfzA:
71.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
SER A 236
GLY A 234
LEU A 239
ILE A 205
 None
MFK  A 401 (-3.4A)
MFK  A 401 ( 3.9A)
MFK  A 401 ( 4.9A)
None
 1.44A 5fepA-4mfzA:
undetectable		 5fepA-4mfzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
SER A 236
GLY A 234
LEU A 239
ILE A 205
 None
MFK  A 401 (-3.4A)
MFK  A 401 ( 3.9A)
MFK  A 401 ( 4.9A)
None
 1.44A 5fesA-4mfzA:
undetectable		 5fesA-4mfzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.80A 5jw1A-4mfzA:
undetectable		 5jw1A-4mfzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.86A 5jw1B-4mfzA:
undetectable		 5jw1B-4mfzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 LEU A 122
GLU A 133
THR A 139
PHE A 219
GLY A 177
 None
 1.24A 5xipC-4mfzA:
undetectable		 5xipC-4mfzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		5 / 12 VAL A 147
TYR A 113
TYR A 109
PRO A  51
LEU A  45
 None
 1.33A 6eliA-4mfzA:
undetectable		 6eliA-4mfzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 7 TYR A 113
LEU A 143
TYR A 109
VAL A  50
 None
 1.37A 6g2pA-4mfzA:
undetectable		 6g2pA-4mfzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4mfz DBV8 PROTEIN
(Nonomuraea
gerenzanensis) 		4 / 6 LEU A 140
THR A 136
ARG A 123
ARG A  47
 None
 1.38A 6gtqB-4mfzA:
undetectable
6gtqD-4mfzA:
undetectable		 6gtqB-4mfzA:
19.41
6gtqD-4mfzA:
10.36