SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A 187
ALA A 182
ALA A 180
LEU A 173
ASP A 115
 None
 1.25A 1rlbE-4mg4A:
undetectable		 1rlbE-4mg4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		4 / 7 ASP A 146
ARG A  11
ALA A 140
ARG A 137
 None
 1.01A 2e5dA-4mg4A:
4.7
2e5dB-4mg4A:
4.5		 2e5dA-4mg4A:
18.13
2e5dB-4mg4A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A  11
GLY A   2
ASP A  78
GLY A 107
ILE A 104
 None
 0.83A 2ieoA-4mg4A:
undetectable		 2ieoA-4mg4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 12 PRO A 218
ASN A 210
VAL A 209
TYR A 226
LEU A 192
 None
None
None
None
CL  A 303 ( 4.8A)
 1.39A 3megA-4mg4A:
1.5		 3megA-4mg4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  41
PHE A  10
ILE A 100
THR A  99
LEU A  85
 None
 1.02A 4n49A-4mg4A:
undetectable		 4n49A-4mg4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		3 / 3 ARG A 137
ASP A 185
TYR A 147
 None
 0.90A 4yo9B-4mg4A:
undetectable		 4yo9B-4mg4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A 113
SER A 116
PRO A 118
PHE A 117
 None
 1.30A 5b8iA-4mg4A:
undetectable		 5b8iA-4mg4A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  45
SER A  46
ASN A 112
LEU A  85
GLU A  86
 CL  A 301 (-3.4A)
None
None
None
None
 1.28A 5nwvA-4mg4A:
undetectable		 5nwvA-4mg4A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A  11
VAL A  74
LEU A  70
ARG A 137
ILE A 109
 None
 1.09A 5vooE-4mg4A:
5.0		 5vooE-4mg4A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4mg4 PHOSPHONOMUTASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  28
VAL A  69
MET A  66
VAL A  49
GLY A  45
 None
None
None
None
CL  A 301 (-3.4A)
 1.12A 5x24A-4mg4A:
undetectable		 5x24A-4mg4A:
19.96