SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 11 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.05A 4c5lA-4mgxA:
undetectable		 4c5lA-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 9 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.05A 4c5lB-4mgxA:
undetectable		 4c5lB-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 10 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.12A 4c5lC-4mgxA:
undetectable		 4c5lC-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 10 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.11A 4c5lD-4mgxA:
undetectable		 4c5lD-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 10 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.06A 4c5nB-4mgxA:
undetectable		 4c5nB-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 10 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.14A 4c5nD-4mgxA:
undetectable		 4c5nD-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4mgx FILAMIN-C
(Homo
sapiens) 		5 / 11 ALA A 656
ILE A 608
GLY A 610
VAL A 586
ILE A 658
 None
 1.17A 5kr2B-4mgxA:
undetectable		 5kr2B-4mgxA:
19.46