SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens)
5 / 12 TYR R  40
GLY R  60
ALA R  59
GLY R  10
LEU R   9
None
None
SO4  R 201 (-3.3A)
None
None
1.01A 1fe2A-4mh0R:
undetectable
1fe2A-4mh0R:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 10 LEU E 797
LEU E 769
ILE E 805
THR E 717
ILE E 718
None
1.37A 1i18A-4mh0E:
undetectable
1i18B-4mh0E:
undetectable
1i18A-4mh0E:
8.93
1i18B-4mh0E:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 10 THR E 717
ILE E 718
LEU E 797
LEU E 769
ILE E 805
None
1.38A 1i18A-4mh0E:
undetectable
1i18B-4mh0E:
undetectable
1i18A-4mh0E:
8.93
1i18B-4mh0E:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens)
5 / 12 TYR R  40
GLY R  60
ALA R  59
GLY R  10
LEU R   9
None
None
SO4  R 201 (-3.3A)
None
None
1.02A 1igxA-4mh0R:
undetectable
1igxA-4mh0R:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.09A 1jffB-4mh0E:
undetectable
1jffB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 ARG E 801
VAL E 974
TRP E 808
None
1.28A 1qw6A-4mh0E:
undetectable
1qw6A-4mh0E:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 ARG E 801
VAL E 974
TRP E 808
None
1.27A 1vagA-4mh0E:
undetectable
1vagA-4mh0E:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 ARG E 801
VAL E 974
TRP E 808
None
1.24A 1zviA-4mh0E:
undetectable
1zviA-4mh0E:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens)
5 / 10 TYR R  32
VAL R  21
GLY R  60
THR R  61
ALA R  59
None
None
None
None
SO4  R 201 (-3.3A)
1.31A 2coiA-4mh0R:
undetectable
2coiB-4mh0R:
undetectable
2coiA-4mh0R:
16.49
2coiB-4mh0R:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens)
5 / 9 TYR R  32
VAL R  21
GLY R  60
THR R  61
ALA R  59
None
None
None
None
SO4  R 201 (-3.3A)
1.39A 2cojA-4mh0R:
undetectable
2cojB-4mh0R:
undetectable
2cojA-4mh0R:
16.49
2cojB-4mh0R:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.10A 2hxfB-4mh0E:
undetectable
2hxfB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.10A 2hxhB-4mh0E:
undetectable
2hxhB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 VAL E 810
TRP E 808
VAL E 974
None
0.99A 2izqC-4mh0E:
undetectable
2izqD-4mh0E:
undetectable
2izqC-4mh0E:
2.67
2izqD-4mh0E:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.10A 2p4nB-4mh0E:
undetectable
2p4nB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 7 ILE R  36
ARG E 892
TYR R  40
TYR R  32
None
1.00A 2qebA-4mh0R:
undetectable
2qebA-4mh0R:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 7 ILE R  36
ARG E 892
TYR R  40
TYR R  32
None
1.00A 2qebB-4mh0R:
undetectable
2qebB-4mh0R:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens)
3 / 3 LYS R  50
ARG R 163
VAL R 162
None
1.11A 2r2vC-4mh0R:
undetectable
2r2vD-4mh0R:
undetectable
2r2vC-4mh0R:
13.77
2r2vD-4mh0R:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 6 ILE E 498
LEU E 500
LEU E 512
ASP E 509
None
0.81A 2rlfA-4mh0E:
undetectable
2rlfD-4mh0E:
undetectable
2rlfA-4mh0E:
5.31
2rlfD-4mh0E:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 ARG E 859
ARG E 979
GLN E 983
GLN R  99
None
1.49A 2vxaA-4mh0E:
undetectable
2vxaC-4mh0E:
undetectable
2vxaE-4mh0E:
undetectable
2vxaA-4mh0E:
7.10
2vxaC-4mh0E:
7.10
2vxaE-4mh0E:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 ARG E 979
GLN E 983
ARG E 859
GLN R  99
None
1.48A 2vxaA-4mh0E:
undetectable
2vxaB-4mh0E:
undetectable
2vxaK-4mh0E:
undetectable
2vxaA-4mh0E:
7.10
2vxaB-4mh0E:
7.10
2vxaK-4mh0E:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 ARG E 979
GLN E 983
ARG E 859
GLN R  99
None
1.49A 2vxaB-4mh0E:
undetectable
2vxaC-4mh0E:
undetectable
2vxaG-4mh0E:
undetectable
2vxaB-4mh0E:
7.10
2vxaC-4mh0E:
7.10
2vxaG-4mh0E:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 ARG E 859
ARG E 979
GLN E 983
GLN R  99
None
1.48A 2vxaD-4mh0E:
undetectable
2vxaF-4mh0E:
undetectable
2vxaI-4mh0E:
undetectable
2vxaD-4mh0E:
7.10
2vxaF-4mh0E:
7.10
2vxaI-4mh0E:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 ARG E 979
GLN E 983
ARG E 859
GLN R  99
None
1.49A 2vxaD-4mh0E:
undetectable
2vxaE-4mh0E:
undetectable
2vxaL-4mh0E:
undetectable
2vxaD-4mh0E:
7.10
2vxaE-4mh0E:
7.10
2vxaL-4mh0E:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 GLN R  99
ARG E 979
GLN E 983
ARG E 859
None
1.45A 2vxaB-4mh0R:
undetectable
2vxaG-4mh0R:
undetectable
2vxaH-4mh0R:
undetectable
2vxaB-4mh0R:
20.00
2vxaG-4mh0R:
20.00
2vxaH-4mh0R:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 ARG E 979
GLN E 983
ARG E 859
GLN R  99
None
1.47A 2vxaH-4mh0E:
undetectable
2vxaI-4mh0E:
undetectable
2vxaJ-4mh0E:
undetectable
2vxaH-4mh0E:
7.10
2vxaI-4mh0E:
7.10
2vxaJ-4mh0E:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 GLN R  99
ARG E 859
ARG E 979
GLN E 983
None
1.46A 2vxaD-4mh0R:
undetectable
2vxaJ-4mh0R:
undetectable
2vxaL-4mh0R:
undetectable
2vxaD-4mh0R:
20.00
2vxaJ-4mh0R:
20.00
2vxaL-4mh0R:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 GLN R  99
ARG E 979
GLN E 983
ARG E 859
None
1.49A 2vxaH-4mh0R:
undetectable
2vxaJ-4mh0R:
undetectable
2vxaK-4mh0R:
undetectable
2vxaH-4mh0R:
20.00
2vxaJ-4mh0R:
20.00
2vxaK-4mh0R:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 GLN R  99
ARG E 979
GLN E 983
ARG E 859
None
1.46A 2vxaA-4mh0R:
undetectable
2vxaK-4mh0R:
undetectable
2vxaL-4mh0R:
undetectable
2vxaA-4mh0R:
20.00
2vxaK-4mh0R:
20.00
2vxaL-4mh0R:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.09A 2wbeB-4mh0E:
undetectable
2wbeB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 SER E 541
GLY E 390
GLY E 392
HR4  E1002 (-3.2A)
HR4  E1002 ( 4.9A)
HR4  E1002 (-3.4A)
0.56A 3bogA-4mh0E:
undetectable
3bogC-4mh0E:
undetectable
3bogA-4mh0E:
undetectable
3bogC-4mh0E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.10A 3dcoB-4mh0E:
undetectable
3dcoB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.08A 3edlB-4mh0E:
undetectable
3edlB-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 5 ILE E 975
THR E 746
PHE E 750
PHE E 829
None
1.07A 3em0A-4mh0E:
undetectable
3em0A-4mh0E:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
5 / 12 GLU E 775
LEU E 532
HIS E 519
LEU E 562
GLY E 571
None
1.08A 3iz0B-4mh0E:
undetectable
3iz0B-4mh0E:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 5 GLU E 576
LEU E 574
HIS E 774
GLY E 571
None
0.93A 3pp1A-4mh0E:
undetectable
3pp1A-4mh0E:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 5 ASP E 572
LEU E 573
ILE E 646
PRO E 645
None
1.21A 3s3vA-4mh0E:
undetectable
3s3vA-4mh0E:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 6 MET E 933
PRO E 524
GLN E 527
PRO E 487
None
1.13A 3vkxA-4mh0E:
undetectable
3vkxA-4mh0E:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 5 ILE E 779
ALA E 937
HIS E 519
MET E 517
None
1.17A 4ac9B-4mh0E:
undetectable
4ac9C-4mh0E:
undetectable
4ac9B-4mh0E:
22.48
4ac9C-4mh0E:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 5 ILE E 779
ALA E 937
HIS E 519
MET E 517
None
1.16A 4acaB-4mh0E:
undetectable
4acaC-4mh0E:
undetectable
4acaB-4mh0E:
22.48
4acaC-4mh0E:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 5 PHE E 403
PHE E 427
ILE E 379
GLY E 382
None
1.03A 4ejjC-4mh0E:
undetectable
4ejjC-4mh0E:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 6 LYS E 643
PRO E 645
LEU E 769
GLU E 768
None
1.39A 4z4cA-4mh0E:
undetectable
4z4cA-4mh0E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 ARG E 785
THR E 715
ASP E 796
None
0.80A 5g5gA-4mh0E:
1.9
5g5gB-4mh0E:
undetectable
5g5gA-4mh0E:
15.80
5g5gB-4mh0E:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 ARG E 315
HIS E 426
ARG E 311
None
1.16A 5iaoC-4mh0E:
undetectable
5iaoC-4mh0E:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
3 / 3 ARG E 315
HIS E 426
ARG E 311
None
1.15A 5iaoF-4mh0E:
undetectable
5iaoF-4mh0E:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
5 / 10 PRO E 884
TYR R  71
ASN R  74
LEU R  56
ASN E 887
None
1.42A 5l1fD-4mh0E:
2.6
5l1fD-4mh0E:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 7 ASN E 794
LEU E 797
VAL E 670
SER E 711
None
1.04A 5m8rA-4mh0E:
undetectable
5m8rA-4mh0E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus
musculus)
4 / 8 ASN E 794
LEU E 797
VAL E 670
SER E 711
None
1.01A 5m8rD-4mh0E:
undetectable
5m8rD-4mh0E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens;
Mus
musculus)
4 / 8 THR R  65
GLN R  63
ASP E 796
GLY E 720
None
0.97A 5nzyA-4mh0R:
undetectable
5nzyA-4mh0R:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4mh0 RAS-RELATED PROTEIN
RAP-1B

(Homo
sapiens)
4 / 7 VAL R 114
ILE R 112
VAL R   8
ALA R  79
None
0.65A 5osrA-4mh0R:
undetectable
5osrA-4mh0R:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Mus
musculus;
Homo
sapiens)
4 / 6 LEU E 893
ASP R  38
GLN R  43
GLU R  37
None
1.25A 6djzC-4mh0E:
1.6
6djzC-4mh0E:
14.68