SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		3 / 3 VAL A 184
ALA A 183
HIS A 152
 None
SO4  A 303 (-3.7A)
SO4  A 305 (-4.3A)
 0.68A 1q23H-4mhbA:
undetectable		 1q23H-4mhbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		3 / 3 VAL A 184
ALA A 183
HIS A 152
 None
SO4  A 303 (-3.7A)
SO4  A 305 (-4.3A)
 0.65A 1q23J-4mhbA:
undetectable		 1q23J-4mhbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 7 TYR A 124
HIS A 121
HIS A 281
TRP A  90
 None
 1.16A 1yvmA-4mhbA:
undetectable		 1yvmA-4mhbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		5 / 12 GLY A 206
VAL A 212
LEU A 271
PRO A 176
ILE A 268
 None
 0.90A 1zq9B-4mhbA:
undetectable		 1zq9B-4mhbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		5 / 12 ASN A 170
VAL A 169
ILE A 165
ALA A 145
ASP A 158
 None
 1.27A 2iyfB-4mhbA:
undetectable		 2iyfB-4mhbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		5 / 12 GLN A 102
LEU A  89
LEU A 107
ASN A 108
GLU A 136
 None
 1.14A 2zw9B-4mhbA:
undetectable		 2zw9B-4mhbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 5 ILE A 268
PRO A 176
PHE A 200
PRO A 199
 None
 1.36A 3bjwC-4mhbA:
undetectable		 3bjwC-4mhbA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 8 LEU A  89
VAL A 127
TYR A  95
TYR A 118
 None
 1.07A 3v81A-4mhbA:
undetectable		 3v81A-4mhbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 8 LEU A  89
VAL A 127
TYR A  95
TYR A 118
 None
 1.03A 3v81C-4mhbA:
undetectable		 3v81C-4mhbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		3 / 3 ASN A 163
GLU A 135
ARG A 132
 None
 0.82A 3wxoA-4mhbA:
undetectable		 3wxoA-4mhbA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 5 ILE A 120
ALA A  99
MET A 134
ARG A 132
 None
 1.34A 4ac9B-4mhbA:
2.7
4ac9C-4mhbA:
2.4		 4ac9B-4mhbA:
21.15
4ac9C-4mhbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 5 ILE A 120
ALA A  99
MET A 134
ARG A 132
 None
 1.34A 4acaB-4mhbA:
2.5
4acaC-4mhbA:
2.5		 4acaB-4mhbA:
21.15
4acaC-4mhbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		5 / 11 TYR A 124
GLU A 173
HIS A 281
LEU A 290
LEU A  91
 None
 1.43A 4m7tA-4mhbA:
2.3		 4m7tA-4mhbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 8 LEU A  89
VAL A 127
TYR A  95
TYR A 118
 None
 1.05A 4pwdC-4mhbA:
undetectable		 4pwdC-4mhbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 5 THR A  59
ALA A  60
THR A  87
TYR A 118
 None
 1.05A 5ecmA-4mhbA:
undetectable		 5ecmA-4mhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 6 THR A  59
ALA A  60
THR A  87
TYR A 118
 None
 0.97A 5ecoA-4mhbA:
undetectable		 5ecoA-4mhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		5 / 12 PHE A  84
VAL A 238
ILE A  24
LEU A 117
VAL A 169
 None
 1.13A 5im2A-4mhbA:
undetectable		 5im2A-4mhbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 7 ARG A 235
ILE A 268
LEU A 207
PHE A 200
 None
 0.93A 5vc0A-4mhbA:
undetectable		 5vc0A-4mhbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4mhb PUTATIVE ALDO/KETO
REDUCTASE
(Yersinia
pestis) 		4 / 4 GLY A  30
LEU A  56
VAL A 238
GLU A 195
 None
 1.24A 5yw0A-4mhbA:
undetectable		 5yw0A-4mhbA:
22.22