SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 729
ILE A 812
LEU A 809
LEU A 852
 None
 0.89A 1eupA-4mhcA:
undetectable		 1eupA-4mhcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 453
LEU A 432
PRO A 397
SER A 400
PHE A 404
 None
 1.28A 1kglA-4mhcA:
undetectable		 1kglA-4mhcA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 546
ILE A 547
VAL A 620
SER A 634
 None
 1.00A 1rs7A-4mhcA:
undetectable		 1rs7A-4mhcA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 801
LEU A 798
ALA A 794
LEU A 705
LEU A 101
 None
 1.07A 1s9pA-4mhcA:
undetectable		 1s9pA-4mhcA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 801
LEU A 798
GLU A 791
LEU A 705
LEU A 101
 None
 0.96A 1s9pA-4mhcA:
undetectable		 1s9pA-4mhcA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 147
LEU A 180
ILE A 181
SER A 176
 None
 1.11A 1sbrA-4mhcA:
undetectable
1sbrB-4mhcA:
undetectable		 1sbrA-4mhcA:
13.72
1sbrB-4mhcA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 620
LEU A 624
PRO A 630
HIS A 633
 None
 0.95A 2ddwA-4mhcA:
undetectable		 2ddwA-4mhcA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 704
LEU A 798
GLY A 711
ALA A 713
 None
 0.94A 2xh9A-4mhcA:
2.0		 2xh9A-4mhcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 547
GLY A 546
PHE A 590
GLY A 636
HIS A 633
 None
 1.22A 2y7wB-4mhcA:
undetectable		 2y7wB-4mhcA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 137
ASN A 124
THR A 108
PRO A 504
LEU A 111
 None
 1.32A 3a51B-4mhcA:
undetectable		 3a51B-4mhcA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 555
PHE A 590
ALA A 134
SER A 634
TYR A 635
 None
 1.40A 3apwB-4mhcA:
undetectable		 3apwB-4mhcA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 675
SER A 706
PRO A 707
PHE A 709
 None
 1.28A 3bjwC-4mhcA:
undetectable		 3bjwC-4mhcA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 599
SER A 576
ILE A 506
PRO A 543
GLY A 505
 None
 1.20A 3ijxB-4mhcA:
undetectable
3ijxD-4mhcA:
undetectable		 3ijxB-4mhcA:
15.74
3ijxD-4mhcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 506
PRO A 543
GLY A 505
LEU A 599
SER A 576
 None
 1.22A 3ik6B-4mhcA:
undetectable
3ik6E-4mhcA:
undetectable		 3ik6B-4mhcA:
15.74
3ik6E-4mhcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 599
SER A 576
ILE A 506
PRO A 543
GLY A 505
 None
 1.22A 3ik6B-4mhcA:
undetectable
3ik6E-4mhcA:
undetectable		 3ik6B-4mhcA:
15.74
3ik6E-4mhcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 599
SER A 576
ILE A 506
PRO A 543
GLY A 505
 None
 1.21A 3iluB-4mhcA:
undetectable
3iluE-4mhcA:
undetectable		 3iluB-4mhcA:
15.74
3iluE-4mhcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 506
PRO A 543
GLY A 505
LEU A 599
SER A 576
 None
 1.20A 3iluB-4mhcA:
undetectable
3iluE-4mhcA:
undetectable		 3iluB-4mhcA:
15.74
3iluE-4mhcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 798
ALA A 794
GLU A 791
LEU A 705
ILE A 716
 None
 1.26A 3olsB-4mhcA:
undetectable		 3olsB-4mhcA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 353
PHE A 421
PHE A 434
VAL A 424
 None
 1.42A 3rv5C-4mhcA:
undetectable
3rv5D-4mhcA:
0.8		 3rv5C-4mhcA:
7.40
3rv5D-4mhcA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 577
TYR A 614
PHE A 138
SER A 503
LEU A 111
 None
 1.28A 3u9fA-4mhcA:
0.0		 3u9fA-4mhcA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 5 SER A 642
GLY A 711
ARG A 718
GLU A 639
 None
 1.18A 4r82A-4mhcA:
undetectable
4r82B-4mhcA:
undetectable		 4r82A-4mhcA:
11.94
4r82B-4mhcA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 539
THR A 558
THR A 509
 None
 0.83A 5aoxB-4mhcA:
undetectable		 5aoxB-4mhcA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 539
THR A 558
THR A 509
 None
 0.76A 5aoxE-4mhcA:
undetectable		 5aoxE-4mhcA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 718
ASN A 588
ASP A 544
 None
 0.85A 5gwxA-4mhcA:
undetectable		 5gwxA-4mhcA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 140
TYR A 612
GLU A 610
LEU A 560
 None
 0.97A 5umwB-4mhcA:
undetectable
5umwE-4mhcA:
undetectable		 5umwB-4mhcA:
6.57
5umwE-4mhcA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		4 / 7 THR A 456
PHE A 453
LEU A 483
SER A 450
 None
 1.07A 5uxcA-4mhcA:
undetectable		 5uxcA-4mhcA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4mhc NUCLEOPORIN NUP157
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 863
ILE A 812
VAL A 728
LEU A 847
TYR A 843
 None
 1.08A 6ajiA-4mhcA:
undetectable		 6ajiA-4mhcA:
22.62