SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		4 / 6 THR A 184
LEU A 181
GLY A 179
TYR A 104
 None
 1.09A 1gtiC-4mhlA:
undetectable		 1gtiC-4mhlA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		3 / 3 ASP A  52
LEU A  45
LEU A  49
 SO4  A 201 (-4.3A)
None
None
 0.50A 1ikeA-4mhlA:
undetectable		 1ikeA-4mhlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		5 / 11 LEU A 192
GLY A 191
LEU A  90
LEU A 140
LEU A  94
 None
 1.40A 1mx1B-4mhlA:
undetectable		 1mx1B-4mhlA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		3 / 3 ASP A  52
LEU A  45
LEU A  49
 SO4  A 201 (-4.3A)
None
None
 0.52A 1np1B-4mhlA:
undetectable		 1np1B-4mhlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		3 / 3 LEU A 122
HIS A 175
ILE A 171
 None
ARF  A 203 (-4.4A)
ARF  A 203 (-4.5A)
 0.69A 1s9pB-4mhlA:
undetectable		 1s9pB-4mhlA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		5 / 12 GLY A 169
GLY A 170
LEU A 119
LEU A 178
HIS A  70
 None
None
None
None
ARF  A 203 (-3.6A)
 1.30A 1ya4B-4mhlA:
undetectable		 1ya4B-4mhlA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		5 / 9 THR A  53
ALA A 188
GLY A 179
GLY A 180
ASP A 100
 None
 1.17A 4qwuK-4mhlA:
undetectable
4qwuL-4mhlA:
undetectable		 4qwuK-4mhlA:
23.87
4qwuL-4mhlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		5 / 12 LEU A  78
LEU A  75
ASN A  71
ALA A 176
ILE A 177
 None
 1.11A 4x1iD-4mhlA:
undetectable		 4x1iD-4mhlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		5 / 12 LEU A  78
LEU A  75
ASN A  71
ALA A 176
ILE A 177
 None
 1.07A 4x1yD-4mhlA:
undetectable		 4x1yD-4mhlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		5 / 11 LEU A  78
LEU A  75
ASN A  71
ALA A 176
ILE A 177
 None
 1.15A 4x20D-4mhlA:
undetectable		 4x20D-4mhlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mhl INTERLEUKIN-11
(Homo
sapiens) 		4 / 8 THR A  53
LEU A  56
LEU A 111
LEU A 126
 None
 0.61A 4z90F-4mhlA:
2.6
4z90G-4mhlA:
4.2
4z90H-4mhlA:
2.6
4z90I-4mhlA:
2.6
4z90J-4mhlA:
2.7		 4z90F-4mhlA:
17.08
4z90G-4mhlA:
17.08
4z90H-4mhlA:
17.08
4z90I-4mhlA:
17.08
4z90J-4mhlA:
17.08