SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mhp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 6 HIS A 322
ASP A 326
ASP A 325
PRO A 318
 None
 1.48A 1ilqA-4mhpA:
undetectable
1ilqC-4mhpA:
undetectable		 1ilqA-4mhpA:
11.84
1ilqC-4mhpA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		5 / 12 THR A 174
LEU A 175
VAL A 233
LEU A 155
TRP A  90
 None
 1.35A 1wsvA-4mhpA:
undetectable		 1wsvA-4mhpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		5 / 12 THR A 174
LEU A 175
VAL A 233
LEU A 155
TRP A  90
 None
 1.31A 1wsvB-4mhpA:
undetectable		 1wsvB-4mhpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 5 PHE A 302
ASN A 110
ILE A 112
ASP A  95
 None
 1.17A 1yc2D-4mhpA:
undetectable		 1yc2D-4mhpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		3 / 3 ASP A 130
PHE A 108
SER A 198
 None
 0.96A 3i5uB-4mhpA:
undetectable		 3i5uB-4mhpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 8 ASP A 144
LEU A 239
ASP A 297
ASP A 298
 None
 1.21A 3n2oC-4mhpA:
undetectable
3n2oD-4mhpA:
undetectable		 3n2oC-4mhpA:
19.79
3n2oD-4mhpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 6 HIS A 322
PRO A 318
LEU A 239
ASP A 297
 None
 1.22A 3oi8A-4mhpA:
undetectable		 3oi8A-4mhpA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 5 HIS A 311
ILE A 309
HIS A 299
LEU A 236
 None
 1.46A 3qpkA-4mhpA:
undetectable		 3qpkA-4mhpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		5 / 12 ASP A 326
PHE A 139
LEU A 132
ASP A 144
HIS A 128
 None
 1.27A 3r2jC-4mhpA:
undetectable		 3r2jC-4mhpA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		5 / 11 SER A 145
PHE A 346
PHE A 343
ASN A 340
ALA A 156
 None
 1.43A 4dx7A-4mhpA:
undetectable		 4dx7A-4mhpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 4 LEU A 163
SER A 158
LEU A  88
LEU A 175
 None
 1.07A 4n09A-4mhpA:
undetectable		 4n09A-4mhpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 5 LEU A 163
SER A 158
LEU A  88
LEU A 175
 None
 1.08A 4n09B-4mhpA:
undetectable		 4n09B-4mhpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 5 LEU A 163
SER A 158
LEU A  88
LEU A 175
 None
 1.07A 4n09D-4mhpA:
undetectable		 4n09D-4mhpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		5 / 11 HIS A 128
ASP A 144
GLU A 183
GLU A 184
HIS A 322
 None
 0.43A 4pqaA-4mhpA:
21.8		 4pqaA-4mhpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		5 / 12 SER A 145
SER A 315
ASP A 298
GLU A 184
GLU A 183
 None
 1.35A 4zjoA-4mhpA:
undetectable		 4zjoA-4mhpA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 5 LEU A 239
LEU A 236
PHE A 317
HIS A 128
 None
 0.97A 5gtrA-4mhpA:
undetectable		 5gtrA-4mhpA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 6 PRO A 318
HIS A 128
ALA A 150
LEU A  60
 None
 1.02A 5igiA-4mhpA:
undetectable		 5igiA-4mhpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 4 LEU A 153
ARG A  67
ILE A  81
PHE A 179
 None
 1.28A 5kirB-4mhpA:
undetectable		 5kirB-4mhpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 6 GLU A 232
LEU A 123
ARG A 122
ARG A  32
 None
 1.24A 5l6eA-4mhpA:
2.1
5l6eB-4mhpA:
1.5		 5l6eA-4mhpA:
21.56
5l6eB-4mhpA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 5 VAL A  77
HIS A 128
LEU A 153
ASP A 181
 None
 1.50A 5vcvA-4mhpA:
undetectable		 5vcvA-4mhpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 8 SER A 337
ARG A  53
GLN A  47
ASN A 338
 None
 1.20A 5vunB-4mhpA:
undetectable		 5vunB-4mhpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 8 SER A 337
ARG A  53
GLN A  47
ASN A 338
 None
 1.23A 5vuoB-4mhpA:
undetectable		 5vuoB-4mhpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mhp GLUTAMINYL CYCLASE,
PUTATIVE
(Ixodes
scapularis) 		4 / 8 SER A 337
ARG A  53
GLN A  47
ASN A 338
 None
 1.25A 6auuB-4mhpA:
undetectable		 6auuB-4mhpA:
21.56