SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		4 / 7 VAL A 236
LEU A  61
VAL A  58
LEU A 111
 None
 0.79A 1cqpA-4mhuA:
undetectable
1cqpB-4mhuA:
undetectable		 1cqpA-4mhuA:
19.50
1cqpB-4mhuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		5 / 12 LEU A 284
HIS A 144
ASP A 146
LEU A 178
HIS A 245
 None
FE  A 401 (-3.7A)
FE  A 401 (-2.6A)
None
FE  A 401 (-3.9A)
 0.98A 1uobA-4mhuA:
10.7		 1uobA-4mhuA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		5 / 12 GLY A  45
VAL A 180
LEU A 243
LEU A  49
LEU A 178
 None
 0.93A 1ya4C-4mhuA:
undetectable		 1ya4C-4mhuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		3 / 3 ASP A 108
PHE A  53
ARG A 110
 None
 0.87A 2a3aA-4mhuA:
undetectable		 2a3aA-4mhuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		4 / 6 PRO A 229
MET A 179
HIS A 245
TYR A  46
 None
None
FE  A 401 (-3.9A)
None
 1.44A 2lh8A-4mhuA:
undetectable		 2lh8A-4mhuA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		4 / 6 GLN A 127
HIS A 144
HIS A 245
ARG A 129
 None
FE  A 401 (-3.7A)
FE  A 401 (-3.9A)
None
 1.09A 3nvcA-4mhuA:
4.8		 3nvcA-4mhuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		4 / 7 ASN A 258
ASP A 146
HIS A 144
HIS A 245
 None
FE  A 401 (-2.6A)
FE  A 401 (-3.7A)
FE  A 401 (-3.9A)
 0.88A 3t01A-4mhuA:
undetectable		 3t01A-4mhuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		3 / 3 ALA A  64
ASN A  67
LEU A  68
 None
 0.36A 5i1nB-4mhuA:
undetectable		 5i1nB-4mhuA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		4 / 6 GLU A 122
LEU A 293
ARG A 294
ARG A 116
 None
 0.67A 5l6eA-4mhuA:
undetectable
5l6eB-4mhuA:
undetectable		 5l6eA-4mhuA:
22.74
5l6eB-4mhuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		3 / 3 TYR A 188
HIS A 151
MET A 156
 None
 1.16A 6af6A-4mhuA:
undetectable		 6af6A-4mhuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		5 / 10 LEU A 105
VAL A 236
VAL A  58
GLY A 234
LEU A 261
 None
 1.36A 6bsiA-4mhuA:
undetectable		 6bsiA-4mhuA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4mhu ECTOINE HYDROXYLASE
(Sphingopyxis
alaskensis) 		3 / 3 TYR A   5
HIS A 151
PHE A 147
 None
 0.95A 6esmA-4mhuA:
undetectable		 6esmA-4mhuA:
13.79