SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mi2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  55
VAL A 202
GLY A 204
ALA A 110
HIS A 187
 None
 1.26A 1kxhA-4mi2A:
undetectable		 1kxhA-4mi2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		3 / 3 LEU A 159
ARG A 158
ILE A 160
 None
 0.64A 2xn5B-4mi2A:
undetectable		 2xn5B-4mi2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 10 ILE A 103
PHE A  65
ALA A 118
LEU A 122
ALA A 123
 None
 1.35A 3lw5B-4mi2A:
undetectable		 3lw5B-4mi2A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 125
ALA A 126
ASP A 127
ILE A 128
ILE A  21
 None
 1.04A 3ogpB-4mi2A:
undetectable		 3ogpB-4mi2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  20
ALA A  55
VAL A  18
ASP A 127
ALA A 126
 None
 1.42A 4df3A-4mi2A:
undetectable		 4df3A-4mi2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 9 VAL A  67
VAL A   9
ALA A   8
THR A  35
ALA A  31
 None
 1.33A 4oqrA-4mi2A:
undetectable		 4oqrA-4mi2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 125
ALA A  47
ILE A  21
LEU A  40
LEU A  41
 None
 1.19A 4xumB-4mi2A:
undetectable		 4xumB-4mi2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 10 ASP A 127
VAL A 107
VAL A  56
LEU A  44
ALA A  99
 None
 1.42A 4yhaB-4mi2A:
undetectable		 4yhaB-4mi2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  68
GLY A 119
GLY A 121
LEU A 122
ALA A  28
 None
 0.94A 5c0oF-4mi2A:
undetectable		 5c0oF-4mi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacteroides
abscessus) 		5 / 10 ALA A 131
ILE A 111
GLY A 138
PHE A 137
GLY A 113
 None
 1.15A 5i6xA-4mi2A:
2.4		 5i6xA-4mi2A:
19.27