SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mi4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 6 GLU A  43
ARG A   8
LEU A  15
ASP A  14
 None
 1.00A 1mt1B-4mi4A:
undetectable
1mt1C-4mi4A:
undetectable		 1mt1B-4mi4A:
18.32
1mt1C-4mi4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 11 VAL A  59
GLU A  72
LEU A  42
ILE A  18
ASP A  14
 None
 1.34A 1t6zB-4mi4A:
undetectable		 1t6zB-4mi4A:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 8 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.11A 4mj8A-4mi4A:
31.8
4mj8C-4mi4A:
30.9		 4mj8A-4mi4A:
100.00
4mj8C-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		8 / 8 TRP A  31
GLU A  33
ILE A  74
GLU A  75
GLU A  84
GLN A  86
ILE A  87
LEU A 121
 None
SPM  A 201 (-3.2A)
None
None
None
None
None
None
 0.12A 4mj8A-4mi4A:
31.8		 4mj8A-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 8 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.12A 4mj8B-4mi4A:
31.2
4mj8C-4mi4A:
30.9		 4mj8B-4mi4A:
100.00
4mj8C-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.41A 4mj8C-4mi4A:
30.9		 4mj8C-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 ALA A  90
ILE A  88
GLY A  69
ASN A  20
PHE A  17
 None
 0.96A 4obwA-4mi4A:
2.8		 4obwA-4mi4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 ALA A  90
ILE A  88
GLY A  69
ASN A  20
PHE A  17
 None
 1.00A 4obwD-4mi4A:
undetectable		 4obwD-4mi4A:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 5 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.71A 4r87E-4mi4A:
29.8		 4r87E-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_G_SPMG202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 9 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.49A 4r87E-4mi4A:
29.8
4r87G-4mi4A:
30.3		 4r87E-4mi4A:
100.00
4r87G-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		6 / 6 ASN A  22
MET A  28
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.72A 4r87H-4mi4A:
29.8		 4r87H-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		7 / 7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.71A 4r87I-4mi4A:
30.1		 4r87I-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 7 MET A  28
TRP A  31
GLU A  33
GLU A  37
GLU A  41
 SPM  A 201 ( 4.5A)
None
SPM  A 201 (-3.2A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.90A 4r87J-4mi4A:
29.6
4r87L-4mi4A:
29.4		 4r87J-4mi4A:
100.00
4r87L-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 7 MET A  28
TRP A  31
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 ( 4.5A)
None
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.60A 4r87J-4mi4A:
29.6
4r87L-4mi4A:
29.4		 4r87J-4mi4A:
100.00
4r87L-4mi4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_K_SPMK202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE
(Vibrio
cholerae) 		8 / 9 ASN A  22
MET A  28
TRP A  31
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
None
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.63A 4r87I-4mi4A:
30.1
4r87K-4mi4A:
29.8		 4r87I-4mi4A:
100.00
4r87K-4mi4A:
100.00