SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
3 / 3 GLY A 709
GLU A 549
ASN A 708
None
0.66A 1zq9A-4mi5A:
undetectable
1zq9A-4mi5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.77A 3ooiA-4mi5A:
15.1
3ooiA-4mi5A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.54A 3opeA-4mi5A:
15.5
3opeA-4mi5A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 VAL A 626
GLY A 628
ASN A 693
HIS A 694
TYR A 731
None
0.83A 3qxyA-4mi5A:
4.9
3qxyA-4mi5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 VAL A 626
GLY A 628
ASN A 693
HIS A 694
TYR A 731
None
0.84A 3rc0B-4mi5A:
4.8
3rc0B-4mi5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 LEU A 727
ALA A 717
LYS A 718
ALA A 720
ILE A 643
None
1.18A 3ut5D-4mi5A:
undetectable
3ut5D-4mi5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 LEU A 619
ILE A 721
ILE A 689
ALA A 692
PHE A 729
None
1.08A 4rp8C-4mi5A:
undetectable
4rp8C-4mi5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.81A 4ynmA-4mi5A:
15.7
4ynmA-4mi5A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.71A 4ynmB-4mi5A:
15.4
4ynmB-4mi5A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 10 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.68A 4ynpB-4mi5A:
15.4
4ynpB-4mi5A:
29.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.66A 4ypaA-4mi5A:
15.2
4ypaA-4mi5A:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.69A 4ypaB-4mi5A:
15.4
4ypaB-4mi5A:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.67A 4ypaC-4mi5A:
15.4
4ypaC-4mi5A:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.73A 4ypaD-4mi5A:
15.6
4ypaD-4mi5A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.80A 4ypeA-4mi5A:
15.2
4ypeA-4mi5A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.64A 4ypeB-4mi5A:
15.3
4ypeB-4mi5A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 4ypuA-4mi5A:
15.4
4ypuA-4mi5A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.44A 4ypuB-4mi5A:
15.3
4ypuB-4mi5A:
29.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.61A 5jhnA-4mi5A:
11.0
5jhnA-4mi5A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 5jhnB-4mi5A:
11.0
5jhnB-4mi5A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5jiyA-4mi5A:
10.9
5jiyA-4mi5A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.66A 5jiyB-4mi5A:
10.5
5jiyB-4mi5A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5jj0B-4mi5A:
10.5
5jj0B-4mi5A:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.66A 5t0kA-4mi5A:
10.7
5t0kA-4mi5A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5t0kB-4mi5A:
11.2
5t0kB-4mi5A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 5t0mB-4mi5A:
10.7
5t0mB-4mi5A:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5ttfA-4mi5A:
10.8
5ttfA-4mi5A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.57A 5ttfB-4mi5A:
10.7
5ttfB-4mi5A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.54A 5ttfC-4mi5A:
10.6
5ttfC-4mi5A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.60A 5ttfD-4mi5A:
10.9
5ttfD-4mi5A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.61A 5ttgA-4mi5A:
10.8
5ttgA-4mi5A:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.61A 5ttgB-4mi5A:
11.0
5ttgB-4mi5A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.61A 5tuyA-4mi5A:
11.0
5tuyA-4mi5A:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.65A 5tuyB-4mi5A:
10.9
5tuyB-4mi5A:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5tuzA-4mi5A:
10.8
5tuzA-4mi5A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 5tuzB-4mi5A:
10.8
5tuzB-4mi5A:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.64A 5updA-4mi5A:
16.1
5updA-4mi5A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.90A 5v21A-4mi5A:
13.5
5v21A-4mi5A:
28.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.61A 5v9iA-4mi5A:
11.0
5v9iA-4mi5A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.57A 5v9iB-4mi5A:
11.1
5v9iB-4mi5A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.64A 5v9iC-4mi5A:
11.1
5v9iC-4mi5A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.64A 5v9jA-4mi5A:
11.0
5v9jA-4mi5A:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5v9jB-4mi5A:
10.8
5v9jB-4mi5A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.64A 5vscA-4mi5A:
11.0
5vscA-4mi5A:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5vscB-4mi5A:
10.8
5vscB-4mi5A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.61A 5vsdA-4mi5A:
10.7
5vsdA-4mi5A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.63A 5vsdB-4mi5A:
10.7
5vsdB-4mi5A:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 5vseA-4mi5A:
10.8
5vseA-4mi5A:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.64A 5vseB-4mi5A:
10.9
5vseB-4mi5A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 5vsfA-4mi5A:
11.0
5vsfA-4mi5A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.62A 5vsfB-4mi5A:
10.8
5vsfB-4mi5A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.75A 6a5kA-4mi5A:
7.3
6a5kA-4mi5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.78A 6a5mA-4mi5A:
9.7
6a5mA-4mi5A:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.80A 6agoA-4mi5A:
15.0
6agoA-4mi5A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 11 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.70A 6cenA-4mi5A:
15.6
6cenA-4mi5A:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo
sapiens)
5 / 12 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
None
0.43A 6ineA-4mi5A:
14.6
6ineA-4mi5A:
29.89