SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 5 THR A 222
GLU A 245
THR A 246
LEU A 140
 None
None
None
GOL  A 404 (-4.2A)
 1.22A 1d4fC-4mioA:
4.1		 1d4fC-4mioA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 5 LYS A  53
ALA A  52
ASP A  64
GLY A   6
 None
 1.14A 1e7bA-4mioA:
2.3		 1e7bA-4mioA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 5 LYS A  53
ALA A  52
ASP A  64
GLY A   6
 None
 1.12A 1e7cA-4mioA:
undetectable		 1e7cA-4mioA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 LEU A 213
LEU A 227
SER A 154
VAL A 150
 None
None
GOL  A 402 (-2.8A)
None
 0.84A 1ictD-4mioA:
undetectable		 1ictD-4mioA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 ALA A 100
LEU A  99
GLY A 307
PHE A 125
GLY A 124
 None
 1.22A 1ru9H-4mioA:
undetectable
1ru9L-4mioA:
undetectable		 1ru9H-4mioA:
19.58
1ru9L-4mioA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.89A 1rxcB-4mioA:
undetectable		 1rxcB-4mioA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.93A 1rxcE-4mioA:
undetectable		 1rxcE-4mioA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.89A 1rxcI-4mioA:
undetectable		 1rxcI-4mioA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.90A 1rxcK-4mioA:
2.1		 1rxcK-4mioA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 LEU A 213
LEU A 227
SER A 154
VAL A 150
 None
None
GOL  A 402 (-2.8A)
None
 0.91A 1tyrB-4mioA:
undetectable		 1tyrB-4mioA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 ALA A  28
VAL A 286
GLY A   6
ILE A  67
ILE A 290
 None
 1.10A 2q5kA-4mioA:
undetectable		 2q5kA-4mioA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 VAL A  73
GLY A  11
ALA A  12
MET A  13
 NAI  A 401 (-4.6A)
NAI  A 401 (-3.3A)
NAI  A 401 (-3.6A)
NAI  A 401 (-4.2A)
 0.89A 2wekB-4mioA:
6.6		 2wekB-4mioA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 VAL A  30
VAL A  31
GLY A   6
THR A  10
GLY A  14
 None
 1.10A 3bjwG-4mioA:
undetectable		 3bjwG-4mioA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 ILE A 170
VAL A 238
ILE A 133
ILE A 178
ALA A 214
 None
 1.10A 3ohtA-4mioA:
undetectable
3ohtB-4mioA:
undetectable		 3ohtA-4mioA:
22.49
3ohtB-4mioA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 LEU A 213
LEU A 227
SER A 154
VAL A 150
 None
None
GOL  A 402 (-2.8A)
None
 0.92A 3ozkB-4mioA:
undetectable		 3ozkB-4mioA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 7 PRO A 197
LEU A 174
TYR A 196
THR A 195
ILE A 194
 None
 1.28A 3p50A-4mioA:
undetectable		 3p50A-4mioA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 7 PRO A 197
LEU A 174
TYR A 196
THR A 195
ILE A 194
 None
 1.27A 3p50B-4mioA:
undetectable		 3p50B-4mioA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 7 PRO A 197
LEU A 174
TYR A 196
THR A 195
ILE A 194
 None
 1.28A 3p50C-4mioA:
undetectable		 3p50C-4mioA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 7 PRO A 197
LEU A 174
TYR A 196
THR A 195
ILE A 194
 None
 1.28A 3p50D-4mioA:
undetectable		 3p50D-4mioA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 7 PRO A 197
LEU A 174
TYR A 196
THR A 195
ILE A 194
 None
 1.27A 3p50E-4mioA:
undetectable		 3p50E-4mioA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 LEU A 174
GLY A 307
ILE A 309
ILE A 170
ILE A 175
 None
 0.91A 3s56B-4mioA:
undetectable		 3s56B-4mioA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 GLY A  14
ALA A  12
ILE A  18
VAL A  73
ILE A   8
 None
NAI  A 401 (-3.6A)
None
NAI  A 401 (-4.6A)
None
 0.96A 4ax8A-4mioA:
5.2		 4ax8A-4mioA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 GLY A  14
ALA A  12
ILE A  18
VAL A  73
ILE A   8
 None
NAI  A 401 (-3.6A)
None
NAI  A 401 (-4.6A)
None
 0.93A 4azvA-4mioA:
5.1		 4azvA-4mioA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 TYR A 129
MET A 126
ILE A 275
 None
NAI  A 401 ( 3.7A)
None
 0.83A 4c8bB-4mioA:
undetectable		 4c8bB-4mioA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.96A 4e1vA-4mioA:
undetectable		 4e1vA-4mioA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.95A 4e1vD-4mioA:
undetectable		 4e1vD-4mioA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 NAI  A 401 ( 4.9A)
None
None
None
 0.95A 4e1vG-4mioA:
2.1		 4e1vG-4mioA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 LEU A 213
LEU A 227
SER A 154
VAL A 150
 None
None
GOL  A 402 (-2.8A)
None
 0.97A 5a6iA-4mioA:
undetectable		 5a6iA-4mioA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 ILE A  67
ALA A  40
ALA A  41
VAL A  45
GLY A  11
 None
NAI  A 401 ( 4.5A)
None
None
NAI  A 401 (-3.3A)
 1.07A 5igjA-4mioA:
undetectable		 5igjA-4mioA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 PRO A 197
TYR A 196
THR A 195
ILE A 194
 None
 0.88A 5mzrE-4mioA:
undetectable		 5mzrE-4mioA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 ILE A  93
ILE A   8
THR A  34
TYR A  55
 None
None
NAI  A 401 ( 4.9A)
None
 0.91A 6cduG-4mioA:
undetectable
6cduH-4mioA:
undetectable		 6cduG-4mioA:
20.89
6cduH-4mioA:
20.89