SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.86A 1jnoA-4mitA:
undetectable		 1jnoA-4mitA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.86A 1jnoB-4mitA:
undetectable		 1jnoB-4mitA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.91A 1jo3A-4mitA:
undetectable		 1jo3A-4mitA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.91A 1jo3B-4mitA:
undetectable		 1jo3B-4mitA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.88A 1magA-4mitA:
undetectable		 1magA-4mitA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.88A 1magB-4mitA:
undetectable		 1magB-4mitA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.87A 1ng8A-4mitA:
undetectable		 1ng8A-4mitA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.87A 1ng8B-4mitA:
undetectable		 1ng8B-4mitA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.92A 1nruA-4mitA:
undetectable		 1nruA-4mitA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 None
 0.92A 1nruB-4mitA:
undetectable		 1nruB-4mitA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		4 / 7 ASP A  18
ASN A  99
TRP A 104
ARG A  75
 None
 1.49A 1rqpB-4mitA:
undetectable		 1rqpB-4mitA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		4 / 7 ASP A  18
ASN A  99
TRP A 104
ARG A  75
 None
 1.50A 2v7uB-4mitA:
undetectable		 2v7uB-4mitA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		5 / 12 PHE A  35
THR A 168
PHE A 176
ILE A 162
ASP A 125
 GTP  A 201 (-4.4A)
None
None
None
GTP  A 201 (-2.9A)
 1.04A 3iv6B-4mitA:
undetectable		 3iv6B-4mitA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		4 / 6 SER A  31
ASP A  64
TYR A  47
PRO A  36
 None
MG  A 202 ( 4.1A)
None
None
 1.40A 3jqaC-4mitA:
3.4		 3jqaC-4mitA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		4 / 6 SER A  31
ASP A  64
TYR A  47
PRO A  36
 None
MG  A 202 ( 4.1A)
None
None
 1.43A 3jqaD-4mitA:
5.4		 3jqaD-4mitA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		5 / 12 GLY A  19
VAL A  15
LEU A  27
CYH A  25
ILE A  40
 GTP  A 201 (-3.5A)
None
None
GTP  A 201 (-3.2A)
None
 1.37A 3mnoA-4mitA:
undetectable		 3mnoA-4mitA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		5 / 12 GLY A  19
VAL A  15
LEU A  27
CYH A  25
ILE A  40
 GTP  A 201 (-3.5A)
None
None
GTP  A 201 (-3.2A)
None
 1.37A 3mnpA-4mitA:
undetectable		 3mnpA-4mitA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ARG A  33
LYS A 173
TYR A  30
 None
 1.29A 6gnaA-4mitA:
undetectable		 6gnaA-4mitA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		3 / 3 ARG A  33
LYS A 173
TYR A  30
 None
 1.29A 6gnbA-4mitA:
undetectable		 6gnbA-4mitA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		4 / 7 ARG A  75
TYR A  79
ASP A  72
GLU A  69
 None
None
MG  A 203 (-3.1A)
None
 1.15A 6mn5B-4mitA:
undetectable		 6mn5B-4mitA:
17.82