SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4miv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 12 PHE A 457
LEU A 461
ALA A 452
LEU A 386
PHE A 384
 None
 1.07A 1og5A-4mivA:
undetectable		 1og5A-4mivA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 GLY A 275
ASP A  32
SER A 272
 None
FGP  A  70 (-3.0A)
None
 0.70A 2qhfA-4mivA:
undetectable		 2qhfA-4mivA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 7 GLN A  93
HIS A  96
HIS A 368
HIS A 125
 None
None
FGP  A  70 ( 4.4A)
FGP  A  70 ( 3.7A)
 1.20A 3ai8A-4mivA:
undetectable		 3ai8A-4mivA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 GLY A 345
ASP A 317
SER A 314
 None
 0.63A 3brfA-4mivA:
undetectable		 3brfA-4mivA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 TYR A 431
LEU A 412
SER A 405
TYR A 403
 None
 0.98A 3rodA-4mivA:
undetectable		 3rodA-4mivA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 7 LEU A 295
GLY A  33
GLU A  36
ALA A  30
 None
 0.94A 3tehB-4mivA:
undetectable		 3tehB-4mivA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 312
GLU A 447
TYR A 286
TYR A 224
 None
 1.17A 3ugrA-4mivA:
undetectable		 3ugrA-4mivA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 6 HIS A 368
HIS A 125
SER A  71
ASP A 477
 FGP  A  70 ( 4.4A)
FGP  A  70 ( 3.7A)
FGP  A  70 ( 4.1A)
None
 1.38A 4blvA-4mivA:
2.2		 4blvA-4mivA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 SER A 364
GLN A  83
ILE A 335
PHE A 101
 None
 0.86A 4dx7B-4mivA:
undetectable		 4dx7B-4mivA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 7 GLY A 127
MET A  88
ASN A  86
GLU A 141
 None
 1.11A 4fgkB-4mivA:
undetectable		 4fgkB-4mivA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 281
ASP A  32
GLU A 447
ASN A 274
LEU A 285
 None
FGP  A  70 (-3.0A)
None
CA  A 601 (-3.0A)
None
 1.10A 4fr0A-4mivA:
undetectable		 4fr0A-4mivA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 6 PRO A 478
ILE A 335
TYR A  89
PHE A 336
 None
 1.06A 4g10A-4mivA:
undetectable		 4g10A-4mivA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 12 VAL A 268
ILE A 155
GLY A 251
GLY A 249
LEU A 263
 None
 0.83A 4iv0A-4mivA:
undetectable		 4iv0A-4mivA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 4 TYR A 333
THR A  79
VAL A 131
ILE A 335
 None
 1.44A 4jx1F-4mivA:
undetectable		 4jx1F-4mivA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 12 VAL A 268
ILE A 155
GLY A 251
GLY A 249
LEU A 263
 None
 0.84A 4mwzB-4mivA:
undetectable		 4mwzB-4mivA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 ARG A 382
GLU A 355
TYR A 312
 None
 0.89A 4r29D-4mivA:
undetectable		 4r29D-4mivA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 SER A  69
GLU A 140
GLU A 129
 FGP  A  70 ( 3.3A)
None
None
 0.61A 4ymgB-4mivA:
undetectable		 4ymgB-4mivA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 ILE A 121
LYS A 156
VAL A 175
GLU A 256
 None
 0.99A 5dqyA-4mivA:
undetectable		 5dqyA-4mivA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 11 GLN A 239
SER A 272
ASP A 273
GLU A 292
LEU A  50
 None
None
CA  A 601 (-2.3A)
None
None
 1.49A 5jh7B-4mivA:
undetectable		 5jh7B-4mivA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 11 GLN A 239
SER A 272
ASP A 273
GLU A 292
LEU A  50
 None
None
CA  A 601 (-2.3A)
None
None
 1.44A 5jh7D-4mivA:
undetectable		 5jh7D-4mivA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 ARG A 435
PRO A 483
ASN A 500
 None
 0.89A 5jwaA-4mivA:
undetectable
5jwaH-4mivA:
undetectable		 5jwaA-4mivA:
19.80
5jwaH-4mivA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 12 TYR A 138
PHE A 136
ILE A 121
ARG A 117
LEU A 173
 None
 1.28A 5zwrB-4mivA:
undetectable		 5zwrB-4mivA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 10 TYR A 215
ASP A 179
THR A 242
THR A  47
SER A  37
 None
 1.49A 6mn1A-4mivA:
undetectable		 6mn1A-4mivA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 ASP A  32
ARG A 182
HIS A 181
ASP A 235
 FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
 1.12A 6mn4A-4mivA:
undetectable		 6mn4A-4mivA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 ASP A  32
ARG A 182
HIS A 181
ASP A 235
 FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
 1.23A 6mn4D-4mivA:
undetectable		 6mn4D-4mivA:
20.43