SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		5 / 12 ASN A2180
ILE A2171
TYR A2274
ALA A2256
SER A2259
 None
UD1  A2502 (-4.2A)
None
UD1  A2502 (-3.6A)
UD1  A2502 (-2.9A)
 1.44A 2iyfB-4mixA:
2.3		 2iyfB-4mixA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		5 / 6 ILE A2169
LYS A2231
PHE A2234
PHE A2243
TYR A2246
 UD1  A2502 (-4.1A)
None
None
None
None
 1.40A 3elzB-4mixA:
undetectable		 3elzB-4mixA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		4 / 6 ILE A2171
LYS A2231
PHE A2234
PHE A2243
 UD1  A2502 (-4.2A)
None
None
None
 1.19A 3elzB-4mixA:
undetectable		 3elzB-4mixA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		5 / 12 ASP A2260
PRO A2348
ASP A2278
ILE A2277
ARG A2263
 UD1  A2502 (-2.9A)
UD1  A2502 (-4.1A)
CA  A2501 ( 2.7A)
UD1  A2502 (-4.5A)
UD1  A2502 (-3.1A)
 0.95A 3topA-4mixA:
undetectable		 3topA-4mixA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		5 / 11 ASN A2180
ILE A2171
TYR A2274
ALA A2256
SER A2259
 None
UD1  A2502 (-4.2A)
None
UD1  A2502 (-3.6A)
UD1  A2502 (-2.9A)
 1.44A 4m83B-4mixA:
undetectable		 4m83B-4mixA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		4 / 5 LEU A2328
ALA A2354
VAL A2317
ILE A2294
 None
 0.94A 4xe3A-4mixA:
undetectable		 4xe3A-4mixA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		6 / 12 VAL A2249
LEU A2265
LEU A2328
ILE A2261
LYS A2254
LEU A2237
 None
 1.37A 4y0sA-4mixA:
undetectable		 4y0sA-4mixA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		4 / 7 ILE A2204
VAL A2223
ILE A2226
PHE A2218
 None
 0.91A 5hieC-4mixA:
undetectable		 5hieC-4mixA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		4 / 6 ILE A2294
LEU A2362
VAL A2296
ARG A2413
 None
 1.18A 6f6jA-4mixA:
undetectable		 6f6jA-4mixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mix PUTATIVE
INSECTICIDAL TOXIN
(Photorhabdus
asymbiotica) 		4 / 8 TYR A2194
ILE A2166
ALA A2316
VAL A2317
 None
 0.83A 6hu9a-4mixA:
undetectable
6hu9e-4mixA:
undetectable		 6hu9a-4mixA:
20.26
6hu9e-4mixA:
18.43