SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		4 / 5 ALA A 108
TYR A  38
ILE A  79
ASP A  40
 None
 1.26A 1upfA-4mj3A:
2.0		 1upfA-4mj3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		4 / 6 PRO A 151
LEU A 260
ARG A 131
GLY A 134
 None
 1.18A 2hs2B-4mj3A:
undetectable		 2hs2B-4mj3A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 VAL A  49
CYH A 121
LEU A 119
THR A 118
THR A 148
 None
 1.21A 3a35B-4mj3A:
undetectable		 3a35B-4mj3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 VAL A  49
CYH A 121
LEU A 119
THR A 118
THR A 148
 None
 1.22A 3a3bA-4mj3A:
undetectable		 3a3bA-4mj3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 LEU A 260
ARG A 131
ALA A 227
GLU A 135
ARG A 237
 None
 1.33A 3k39D-4mj3A:
undetectable		 3k39D-4mj3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 LEU A 260
ARG A 131
ALA A 227
GLU A 135
ARG A 237
 None
 1.34A 3k39N-4mj3A:
undetectable		 3k39N-4mj3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 LEU A 260
ARG A 131
ALA A 227
GLU A 135
ARG A 237
 None
 1.33A 3k39O-4mj3A:
undetectable		 3k39O-4mj3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 LEU A 260
ARG A 131
ALA A 227
GLU A 135
ARG A 237
 None
 1.33A 3k39P-4mj3A:
undetectable		 3k39P-4mj3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 THR A 148
LEU A 119
VAL A 133
LEU A 260
PHE A 246
 None
 1.17A 3tbgA-4mj3A:
undetectable		 3tbgA-4mj3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 10 THR A 148
LEU A 119
VAL A 133
LEU A 260
PHE A 246
 None
 1.19A 3tbgC-4mj3A:
undetectable		 3tbgC-4mj3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 VAL A  48
ALA A 115
PHE A 140
MET A 105
LEU A  52
 None
 1.38A 4eilA-4mj3A:
undetectable		 4eilA-4mj3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 VAL A  48
ALA A 115
PHE A 140
MET A 105
LEU A  52
 None
 1.41A 4eilC-4mj3A:
undetectable		 4eilC-4mj3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 VAL A  48
ALA A 115
PHE A 140
MET A 105
LEU A  52
 None
 1.39A 4eilE-4mj3A:
undetectable		 4eilE-4mj3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 10 VAL A  48
ALA A 115
PHE A 140
MET A 105
LEU A  52
 None
 1.44A 4eilG-4mj3A:
undetectable		 4eilG-4mj3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 HIS A 280
GLU A 284
LEU A  14
ASP A 197
GLY A 177
 None
 1.19A 4foxA-4mj3A:
undetectable		 4foxA-4mj3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 HIS A 280
GLU A 284
LEU A  14
ASP A 197
GLY A 177
 None
 1.22A 4foxC-4mj3A:
undetectable		 4foxC-4mj3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 HIS A 280
GLU A 284
LEU A  14
ASP A 197
GLY A 177
 None
 1.18A 4foxF-4mj3A:
undetectable		 4foxF-4mj3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 HIS A 280
GLU A 284
LEU A  14
ASP A 197
GLY A 177
 None
 1.23A 4foxG-4mj3A:
undetectable		 4foxG-4mj3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 LEU A  81
TRP A 124
ARG A 131
ALA A 231
GLU A 135
 None
CL  A 401 (-4.7A)
None
None
None
 1.43A 4mx0A-4mj3A:
undetectable		 4mx0A-4mj3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 11 LEU A 282
LEU A  61
ILE A 179
GLY A 177
LEU A 188
 None
 1.24A 4pxmB-4mj3A:
undetectable		 4pxmB-4mj3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		5 / 12 GLY A  54
GLY A 125
GLY A 126
LEU A 127
ALA A 209
 None
 0.94A 5c0oF-4mj3A:
undetectable		 5c0oF-4mj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		4 / 6 GLN A 270
PHE A 238
THR A 148
PHE A 246
 None
 1.45A 5mwyA-4mj3A:
undetectable		 5mwyA-4mj3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		4 / 5 GLN A 122
THR A 148
THR A 118
LEU A 290
 None
 1.37A 6aphA-4mj3A:
5.0		 6aphA-4mj3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 4mj3 HALOALKANE
DEHALOGENASE
(Mycolicibacteriu
m
rhodesiae) 		4 / 4 GLN A 122
THR A 148
THR A 118
LEU A 290
 None
 1.40A 6f3mA-4mj3A:
7.0		 6f3mA-4mj3A:
18.42