SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 SER A 152
PHE A  14
GLU A 154
GLY A  13
 None
 1.41A 1icvA-4mjkA:
undetectable
1icvB-4mjkA:
undetectable		 1icvA-4mjkA:
22.46
1icvB-4mjkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 154
GLY A  13
SER A 152
PHE A  14
 None
 1.30A 1kqbA-4mjkA:
undetectable
1kqbB-4mjkA:
undetectable		 1kqbA-4mjkA:
21.68
1kqbB-4mjkA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 PHE A  14
TYR A 201
PRO A  31
 None
 1.18A 1mcnA-4mjkA:
undetectable
1mcnB-4mjkA:
undetectable
1mcnP-4mjkA:
undetectable		 1mcnA-4mjkA:
20.59
1mcnB-4mjkA:
20.59
1mcnP-4mjkA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 147
LEU A 144
ALA A  39
PHE A 134
 None
 0.98A 2opxA-4mjkA:
undetectable		 2opxA-4mjkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  62
LEU A  66
ILE A 143
VAL A 260
VAL A   6
 None
 1.30A 2pnjB-4mjkA:
undetectable		 2pnjB-4mjkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 132
ILE A  69
PRO A  78
PHE A  10
VAL A  40
 None
 0.96A 2ygqA-4mjkA:
undetectable		 2ygqA-4mjkA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 PRO A  78
GLY A 114
THR A 116
SER A 110
ILE A  18
 None
 1.13A 3iv6A-4mjkA:
undetectable		 3iv6A-4mjkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 PRO A  78
GLY A 114
THR A 116
SER A 110
ILE A  18
 None
 1.29A 3iv6C-4mjkA:
undetectable		 3iv6C-4mjkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 THR A  34
PRO A  33
TYR A  30
VAL A   6
ILE A 147
 None
 1.42A 4eb6B-4mjkA:
undetectable
4eb6C-4mjkA:
undetectable		 4eb6B-4mjkA:
19.96
4eb6C-4mjkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 CYH A  76
ASN A 122
LYS A 127
 None
 1.21A 4k50A-4mjkA:
undetectable		 4k50A-4mjkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 THR A  24
LEU A  21
LEU A 202
THR A  35
 None
 0.88A 4z90A-4mjkA:
undetectable
4z90B-4mjkA:
undetectable
4z90C-4mjkA:
undetectable
4z90D-4mjkA:
undetectable
4z90E-4mjkA:
undetectable		 4z90A-4mjkA:
21.73
4z90B-4mjkA:
21.73
4z90C-4mjkA:
21.73
4z90D-4mjkA:
21.73
4z90E-4mjkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 7 TYR A 201
ALA A  16
GLU A 199
GLY A 114
GLY A  20
 None
 1.18A 5e26A-4mjkA:
undetectable
5e26B-4mjkA:
undetectable		 5e26A-4mjkA:
21.95
5e26B-4mjkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 7 GLU A 199
GLY A 114
GLY A  20
TYR A 201
ALA A  16
 None
 1.24A 5e26C-4mjkA:
undetectable
5e26D-4mjkA:
undetectable		 5e26C-4mjkA:
21.95
5e26D-4mjkA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 132
PRO A 231
ILE A 230
PHE A 180
PRO A 204
 None
 1.43A 5ewjC-4mjkA:
undetectable
5ewjD-4mjkA:
undetectable		 5ewjC-4mjkA:
22.67
5ewjD-4mjkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 252
LYS A 135
ASN A  65
GLU A 136
GLU A 137
 None
 1.27A 5nwuA-4mjkA:
undetectable		 5nwuA-4mjkA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 138
LEU A  37
LEU A  62
ILE A  59
ILE A  58
 None
 1.44A 5uanB-4mjkA:
undetectable		 5uanB-4mjkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_C_9F2C302_1
(BETA-LACTAMASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 THR A  35
ILE A  18
PRO A  32
THR A 116
ASP A 109
 None
 1.42A 6b5yC-4mjkA:
0.0
6b5yD-4mjkA:
0.0		 6b5yC-4mjkA:
16.05
6b5yD-4mjkA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_A_9F2A302_1
(BETA-LACTAMASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 9 THR A  35
ILE A  18
PRO A  32
THR A 116
ASP A 109
 None
 1.47A 6b68A-4mjkA:
undetectable
6b68B-4mjkA:
undetectable		 6b68A-4mjkA:
16.05
6b68B-4mjkA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 THR A  35
ILE A  18
PRO A  32
THR A 116
ASP A 109
 None
 1.50A 6b68C-4mjkA:
undetectable
6b68D-4mjkA:
undetectable		 6b68C-4mjkA:
16.05
6b68D-4mjkA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 132
THR A  34
PRO A 181
ARG A 229
 None
 1.18A 6ew0B-4mjkA:
undetectable		 6ew0B-4mjkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 132
THR A  34
PRO A 181
ARG A 229
 None
 1.18A 6ew0D-4mjkA:
undetectable		 6ew0D-4mjkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 132
THR A  34
PRO A 181
ARG A 229
 None
 1.18A 6ew0H-4mjkA:
undetectable		 6ew0H-4mjkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4mjk CRISPR PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 132
THR A  34
PRO A 181
ARG A 229
 None
 1.18A 6ew0I-4mjkA:
undetectable		 6ew0I-4mjkA:
14.58