SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.77A 1ddrA-4mjzA:
undetectable		 1ddrA-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 1.03A 1ddsB-4mjzA:
undetectable		 1ddsB-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.87A 1dhiA-4mjzA:
undetectable		 1dhiA-4mjzA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.88A 1dhjA-4mjzA:
undetectable		 1dhjA-4mjzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.86A 1draA-4mjzA:
undetectable		 1draA-4mjzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.86A 1drbA-4mjzA:
undetectable		 1drbA-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.96A 1dreA-4mjzA:
undetectable		 1dreA-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		4 / 6 THR A 139
LEU A 111
GLY A 137
LYS A  79
 None
 1.18A 1gtiC-4mjzA:
undetectable		 1gtiC-4mjzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ILE A 109
PHE A  25
ALA A 135
LEU A 282
PHE A 161
 None
 1.21A 1og5B-4mjzA:
undetectable		 1og5B-4mjzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.86A 1rg7A-4mjzA:
undetectable		 1rg7A-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 1.02A 1rx3A-4mjzA:
undetectable		 1rx3A-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.84A 2drcA-4mjzA:
undetectable		 2drcA-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		4 / 6 LEU A  40
TYR A 302
ILE A 289
GLY A 258
 None
 0.85A 2du8A-4mjzA:
undetectable		 2du8A-4mjzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		4 / 6 LEU A  40
TYR A 302
ILE A 289
GLY A 258
 None
 0.85A 2du8B-4mjzA:
undetectable		 2du8B-4mjzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.86A 3drcA-4mjzA:
undetectable		 3drcA-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.95A 3ia4A-4mjzA:
undetectable		 3ia4A-4mjzA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.97A 3ia4C-4mjzA:
undetectable		 3ia4C-4mjzA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.96A 3ia4D-4mjzA:
undetectable		 3ia4D-4mjzA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 GLY A  92
GLY A  89
LEU A  96
PHE A  84
ALA A  57
 None
 1.04A 3kkzA-4mjzA:
undetectable		 3kkzA-4mjzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 LEU A  40
LEU A 266
ILE A 254
GLY A 273
LEU A 274
 None
 1.07A 3q95B-4mjzA:
undetectable		 3q95B-4mjzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 1.03A 3tq9A-4mjzA:
undetectable		 3tq9A-4mjzA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.89A 4dfrA-4mjzA:
undetectable		 4dfrA-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 1.07A 4ky8B-4mjzA:
undetectable		 4ky8B-4mjzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.97A 4ky8C-4mjzA:
undetectable		 4ky8C-4mjzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 11 LEU A  40
LEU A 266
ILE A 254
GLY A 273
LEU A 274
 None
 1.07A 4pxmB-4mjzA:
undetectable		 4pxmB-4mjzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.98A 4qi9A-4mjzA:
undetectable		 4qi9A-4mjzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.86A 4qi9B-4mjzA:
undetectable		 4qi9B-4mjzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 11 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 0.95A 4qleB-4mjzA:
undetectable		 4qleB-4mjzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 ALA A 256
LEU A 274
SER A  38
ILE A  33
ARG A 222
 None
 1.06A 5hi6A-4mjzA:
undetectable		 5hi6A-4mjzA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 10 ALA A 113
SER A  82
GLY A 137
ALA A 129
SER A 128
 None
 1.15A 5l66K-4mjzA:
undetectable
5l66L-4mjzA:
undetectable		 5l66K-4mjzA:
21.67
5l66L-4mjzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 10 ALA A 113
SER A  82
GLY A 137
ALA A 129
SER A 128
 None
 1.14A 5l66Y-4mjzA:
undetectable
5l66Z-4mjzA:
undetectable		 5l66Y-4mjzA:
21.67
5l66Z-4mjzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		5 / 12 GLY A  43
SER A 286
ASN A 300
GLN A 298
LEU A 295
 None
 1.26A 5nwuA-4mjzA:
undetectable		 5nwuA-4mjzA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		4 / 5 ARG A 198
ALA A 197
TYR A 193
GLN A 195
 None
 1.14A 6f6sA-4mjzA:
undetectable
6f6sB-4mjzA:
undetectable		 6f6sA-4mjzA:
14.29
6f6sB-4mjzA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Toxoplasma
gondii) 		4 / 6 ARG A 115
ALA A 113
LEU A 111
ALA A 129
 None
 1.23A 6fosB-4mjzA:
undetectable		 6fosB-4mjzA:
12.62