SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 381
GLU A 291
LEU A 421
GLY A 427
LEU A 429
 None
 1.25A 1g50B-4mk0A:
undetectable		 1g50B-4mk0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 11 LEU A 381
GLU A 291
LEU A 421
GLY A 427
LEU A 429
 None
 1.24A 1g50C-4mk0A:
undetectable		 1g50C-4mk0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 LEU A 279
ILE A 254
GLY A 304
ILE A 302
ILE A 323
 None
 1.01A 1hpvA-4mk0A:
undetectable		 1hpvA-4mk0A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 352
THR A 353
ALA A 349
SER A 350
GLY A 337
 None
 1.29A 1nbiC-4mk0A:
undetectable		 1nbiC-4mk0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 352
THR A 353
ALA A 349
SER A 350
GLY A 337
 None
 1.30A 1nbiD-4mk0A:
undetectable		 1nbiD-4mk0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 ASP A 169
HIS A  75
ASP A  70
 None
 0.82A 1nw5A-4mk0A:
undetectable		 1nw5A-4mk0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
VAL A 255
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
29X  A 702 (-4.8A)
None
29X  A 702 (-4.6A)
 1.00A 1t46A-4mk0A:
21.4		 1t46A-4mk0A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 PHE A 171
LEU A  47
PHE A 165
SER A  60
 None
 1.25A 1wrkB-4mk0A:
undetectable		 1wrkB-4mk0A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 LEU A 279
ILE A 254
GLY A 304
ILE A 302
ILE A 323
 None
 1.08A 2avoA-4mk0A:
undetectable		 2avoA-4mk0A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 583
ARG A 579
MET A 565
LEU A 632
 None
 1.04A 2dyrA-4mk0A:
2.6
2dyrJ-4mk0A:
undetectable		 2dyrA-4mk0A:
20.70
2dyrJ-4mk0A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 583
ARG A 579
MET A 565
LEU A 632
 None
 1.00A 2dysA-4mk0A:
undetectable
2dysJ-4mk0A:
undetectable		 2dysA-4mk0A:
20.70
2dysJ-4mk0A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 ARG A 316
ASP A 335
ASP A 278
 None
29X  A 702 (-4.4A)
29X  A 702 ( 4.8A)
 0.79A 2ejtA-4mk0A:
undetectable		 2ejtA-4mk0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 LEU A 377
ILE A 323
GLY A 304
HIS A 309
 None
 0.95A 2otfA-4mk0A:
undetectable		 2otfA-4mk0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 8 TYR A  86
ILE A 153
PHE A  59
TYR A 112
 None
 0.83A 2w98B-4mk0A:
undetectable		 2w98B-4mk0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 9 VAL A 205
ALA A 218
LEU A 271
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 ( 4.7A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.84A 2xp2A-4mk0A:
9.0		 2xp2A-4mk0A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
 29X  A 702 (-4.7A)
None
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
 1.16A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.78A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.95A 2y7jA-4mk0A:
23.3		 2y7jA-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.85A 2y7jB-4mk0A:
30.9		 2y7jB-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.88A 2y7jB-4mk0A:
30.9		 2y7jB-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.72A 2y7jB-4mk0A:
30.9		 2y7jB-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.82A 2y7jC-4mk0A:
30.4		 2y7jC-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.72A 2y7jC-4mk0A:
30.4		 2y7jC-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.90A 2y7jD-4mk0A:
30.4		 2y7jD-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
None
29X  A 702 (-4.6A)
 0.79A 2y7jD-4mk0A:
30.4		 2y7jD-4mk0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 218
LYS A 220
GLU A 239
VAL A 255
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
None
None
29X  A 702 (-4.6A)
 0.82A 2zvaA-4mk0A:
15.6		 2zvaA-4mk0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 583
ARG A 579
MET A 565
LEU A 632
 None
 1.00A 3abmA-4mk0A:
2.5
3abmJ-4mk0A:
undetectable		 3abmA-4mk0A:
20.70
3abmJ-4mk0A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 10 ALA A 218
LYS A 220
VAL A 255
LEU A 271
LEU A 273
MET A 274
GLY A 276
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.88A 3aoxA-4mk0A:
21.5		 3aoxA-4mk0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 10 ALA A 218
LYS A 220
VAL A 255
LEU A 271
LEU A 273
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
None
29X  A 702 (-4.6A)
 0.76A 3aoxA-4mk0A:
21.5		 3aoxA-4mk0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 583
ARG A 579
MET A 565
LEU A 632
 None
 0.97A 3asnA-4mk0A:
2.5
3asnJ-4mk0A:
undetectable		 3asnA-4mk0A:
20.70
3asnJ-4mk0A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 583
ARG A 579
MET A 565
LEU A 632
 None
 0.95A 3asoA-4mk0A:
2.4
3asoJ-4mk0A:
undetectable		 3asoA-4mk0A:
20.70
3asoJ-4mk0A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 8 GLU A 181
SER A 514
GLN A 518
VAL A 525
 None
 1.25A 3b9lA-4mk0A:
2.7		 3b9lA-4mk0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 218
LYS A 220
GLU A 239
LEU A 243
LEU A 273
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
29X  A 702 (-4.6A)
 0.51A 3hecA-4mk0A:
22.7		 3hecA-4mk0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
MET A 274
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
None
None
 1.26A 3hegA-4mk0A:
22.4		 3hegA-4mk0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 8 ALA A 218
LYS A 220
GLU A 239
LEU A 273
MET A 274
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
None
 0.99A 3lfaA-4mk0A:
22.9		 3lfaA-4mk0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 ASP A 373
ARG A 316
ALA A 372
 None
 0.78A 3mbgC-4mk0A:
1.4		 3mbgC-4mk0A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 ALA A 218
LYS A 220
VAL A 255
MET A 274
LEU A 324
SER A 334
ASP A 335
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 0.93A 3miyA-4mk0A:
15.9		 3miyA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 LYS A 220
VAL A 255
MET A 274
GLY A 277
LEU A 324
SER A 334
ASP A 335
 29X  A 702 (-3.6A)
29X  A 702 (-4.8A)
None
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 0.89A 3miyA-4mk0A:
15.9		 3miyA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 ALA A 218
LYS A 220
MET A 274
LEU A 324
SER A 334
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
 0.68A 3miyB-4mk0A:
21.8		 3miyB-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ALA A 128
VAL A 132
TYR A 112
ILE A 113
ILE A  89
 None
 1.36A 3retA-4mk0A:
undetectable
3retB-4mk0A:
undetectable		 3retA-4mk0A:
10.62
3retB-4mk0A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 7 ASP A 293
VAL A 331
GLY A 329
ILE A 471
 None
 0.76A 3ufnB-4mk0A:
undetectable		 3ufnB-4mk0A:
10.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		11 / 12 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
LEU A 324
SER A 334
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 ( 4.3A)
 0.47A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		11 / 12 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
SER A 334
ASP A 335
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
29X  A 702 ( 4.3A)
 0.61A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
GLY A 203
VAL A 205
ALA A 218
VAL A 255
SER A 334
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 1.26A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 271
MET A 274
ASP A 278
 29X  A 702 ( 4.7A)
None
29X  A 702 ( 4.8A)
 0.23A 3v5wA-4mk0A:
56.2		 3v5wA-4mk0A:
97.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 218
LEU A 271
LEU A 273
MET A 274
ASP A 335
 29X  A 702 (-3.1A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.4A)
 0.48A 3zbfA-4mk0A:
23.5		 3zbfA-4mk0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 VAL A 205
ILE A 254
MET A 274
ILE A 333
 29X  A 702 (-4.7A)
None
None
None
 0.77A 4c8bA-4mk0A:
13.2		 4c8bA-4mk0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 PHE A 171
VAL A  53
GLU A  48
 None
 0.83A 4fvqA-4mk0A:
21.4		 4fvqA-4mk0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
ASP A 278
ASP A 317
LYS A 319
ASN A 322
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 ( 4.8A)
None
None
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.92A 4i41A-4mk0A:
18.2		 4i41A-4mk0A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 11 VAL A 205
ALA A 218
LYS A 220
LEU A 271
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.4A)
 0.50A 4iaaA-4mk0A:
18.2		 4iaaA-4mk0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 243
MET A 257
ASP A 278
 None
None
29X  A 702 ( 4.8A)
 0.74A 4j7xB-4mk0A:
undetectable		 4j7xB-4mk0A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
LYS A 220
LEU A 271
GLY A 277
ASP A 278
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
None
29X  A 702 ( 4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 1.01A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 218
LYS A 220
LEU A 271
LEU A 273
GLY A 276
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.88A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 218
LYS A 220
LEU A 271
LEU A 273
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.82A 4mkcA-4mk0A:
13.8		 4mkcA-4mk0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 GLY A 198
VAL A 205
ALA A 218
LYS A 220
ASN A 322
LEU A 324
ASP A 335
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.92A 4o0sA-4mk0A:
22.9		 4o0sA-4mk0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 PHE A 453
PHE A 452
LEU A 429
PRO A 390
 None
 1.28A 4o8zA-4mk0A:
undetectable		 4o8zA-4mk0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 8 PHE A 191
THR A 263
SER A 268
ASP A 265
 None
 1.07A 4qb9D-4mk0A:
undetectable		 4qb9D-4mk0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 GLU A 537
THR A 533
GLN A 176
LEU A  67
 None
 1.03A 4qzuC-4mk0A:
undetectable		 4qzuC-4mk0A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 197
ALA A 218
LYS A 220
PHE A 269
LEU A 273
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
 0.52A 4rz7A-4mk0A:
25.4		 4rz7A-4mk0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 197
ALA A 218
PHE A 269
LEU A 273
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.6A)
 0.60A 4rz7A-4mk0A:
25.4		 4rz7A-4mk0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 273
MET A 274
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.42A 4xoyA-4mk0A:
19.4		 4xoyA-4mk0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 273
MET A 274
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.6A)
 0.42A 4xp3A-4mk0A:
26.5		 4xp3A-4mk0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 LYS A 215
GLY A 214
ASP A 190
TYR A 259
ILE A 270
 None
 1.15A 4ypeA-4mk0A:
undetectable		 4ypeA-4mk0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 11 LYS A 215
GLY A 214
ASP A 190
TYR A 259
ILE A 270
 None
 1.24A 4ypeB-4mk0A:
undetectable		 4ypeB-4mk0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 PHE A 453
LEU A 425
GLY A 378
ILE A 302
 None
 0.91A 5ik1A-4mk0A:
2.1		 5ik1A-4mk0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 VAL A 521
SER A 514
MET A 257
 None
 0.78A 5ikqA-4mk0A:
undetectable		 5ikqA-4mk0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 7 GLY A 198
GLY A 200
GLY A 203
VAL A 205
LEU A 222
 29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
None
 0.40A 5izjB-4mk0A:
26.8		 5izjB-4mk0A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 7 GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
 29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
None
 0.52A 5izjA-4mk0A:
36.2		 5izjA-4mk0A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 ILE A 197
GLY A 198
VAL A 205
ALA A 218
MET A 274
 29X  A 702 (-4.7A)
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
 0.67A 5lw1B-4mk0A:
23.7		 5lw1B-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
 0.78A 5lw1E-4mk0A:
23.4		 5lw1E-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
 0.83A 5lw1H-4mk0A:
23.7		 5lw1H-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
GLY A 198
VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 271
 29X  A 702 (-4.7A)
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 ( 4.7A)
 0.49A 5mafA-4mk0A:
29.2		 5mafA-4mk0A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 197
VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 271
GLY A 277
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 ( 4.7A)
None
 0.81A 5mafA-4mk0A:
29.2		 5mafA-4mk0A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 218
LYS A 220
GLY A 277
LEU A 324
SER A 334
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
 0.87A 5p9iA-4mk0A:
15.8		 5p9iA-4mk0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 MET A 380
LEU A 381
ILE A 333
LEU A 305
LEU A 279
 None
 1.21A 5toaB-4mk0A:
undetectable		 5toaB-4mk0A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 218
LYS A 220
GLY A 277
LEU A 324
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.97A 5yu9D-4mk0A:
15.1		 5yu9D-4mk0A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 180
ILE A  32
VAL A 521
LEU A  67
LEU A  63
 None
 1.05A 6ajiA-4mk0A:
undetectable		 6ajiA-4mk0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 HIS A  75
ASN A  74
LEU A  73
 None
 0.82A 6f7lB-4mk0A:
undetectable		 6f7lB-4mk0A:
21.86