SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLY A 150
HIS A 152
THR A 154
ALA A 143
THR A 140
 None
None
None
None
PG4  A 303 ( 4.1A)
 1.03A 2gluA-4mk3A:
undetectable		 2gluA-4mk3A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 5 LEU A 135
ALA A 137
TRP A  93
LEU A  96
 None
PG4  A 303 (-3.6A)
PG4  A 303 (-2.9A)
PG4  A 303 ( 4.1A)
 1.12A 2oaxA-4mk3A:
undetectable		 2oaxA-4mk3A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 4 ALA A 156
VAL A 160
ASP A 157
LEU A 142
 None
 0.97A 4e7gA-4mk3A:
undetectable		 4e7gA-4mk3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.11A 4hvcA-4mk3A:
undetectable		 4hvcA-4mk3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.08A 4hvcB-4mk3A:
undetectable		 4hvcB-4mk3A:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 8 SER A   9
ARG A 108
TYR A 166
ARG A 170
 GSF  A 304 (-2.4A)
None
None
None
 0.56A 4ijiF-4mk3A:
27.6		 4ijiF-4mk3A:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 7 SER A   9
ARG A 108
TYR A 166
ARG A 170
 GSF  A 304 (-2.4A)
None
None
None
 0.58A 4ijiH-4mk3A:
27.0		 4ijiH-4mk3A:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.13A 4olfA-4mk3A:
undetectable		 4olfA-4mk3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 ALA A  97
MET A 138
LEU A 164
ALA A 165
ILE A 131
 None
 0.87A 4pssA-4mk3A:
undetectable		 4pssA-4mk3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 PHE A 196
GLU A  21
VAL A  18
PHE A 186
GLY A 150
 None
 1.50A 4ydqB-4mk3A:
undetectable		 4ydqB-4mk3A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.11A 5xipA-4mk3A:
undetectable		 5xipA-4mk3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.10A 5xipC-4mk3A:
undetectable		 5xipC-4mk3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.23A 5xiqA-4mk3A:
undetectable		 5xiqA-4mk3A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		5 / 12 GLU A  21
VAL A  18
PHE A 186
THR A 146
GLY A 150
 None
 1.25A 5xiqD-4mk3A:
undetectable		 5xiqD-4mk3A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4mk3 GLUTATHIONE
S-TRANSFERASE
(Cupriavidus
metallidurans) 		4 / 8 ALA A 104
GLY A  99
LEU A 100
ALA A 163
 None
 0.70A 6mdqA-4mk3A:
2.8		 6mdqA-4mk3A:
14.86