SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 4 ILE B 225
LEU B  53
VAL B   5
ILE B  26
 None
 0.91A 1fm6D-4mkiB:
undetectable		 1fm6D-4mkiB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.10A 1p7lC-4mkiB:
undetectable		 1p7lC-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.10A 1p7lD-4mkiB:
undetectable		 1p7lD-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.11A 1rg9A-4mkiB:
undetectable		 1rg9A-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.09A 1rg9B-4mkiB:
undetectable		 1rg9B-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.09A 1rg9C-4mkiB:
undetectable		 1rg9C-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 SER B 244
THR B 249
PHE B 232
ASP B 206
 None
 1.09A 1rg9D-4mkiB:
undetectable		 1rg9D-4mkiB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 7 PHE B  35
ILE B 129
ILE B 189
THR B 197
 None
None
LMT  B 302 ( 4.6A)
None
 0.94A 1sbrB-4mkiB:
undetectable		 1sbrB-4mkiB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 12 ILE B  30
LEU B  53
ASN B  54
VAL B  36
ILE B  81
 None
 1.04A 2nnhA-4mkiB:
undetectable		 2nnhA-4mkiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 4 LYS B 120
ALA B 106
PHE B 107
GLY B 108
 None
 1.05A 2rddA-4mkiB:
undetectable		 2rddA-4mkiB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 12 LEU B 267
ILE B  38
LEU B  49
ILE B  26
MET B 217
 None
 1.15A 2ygnA-4mkiB:
undetectable		 2ygnA-4mkiB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 12 ILE B 225
ILE B 166
LEU B  53
VAL B   5
ILE B  26
 None
 1.01A 3adsB-4mkiB:
undetectable		 3adsB-4mkiB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 ARG B 229
ALA B 208
THR B 249
ILE B 248
 None
 0.81A 3bpxA-4mkiB:
undetectable
3bpxB-4mkiB:
undetectable		 3bpxA-4mkiB:
20.75
3bpxB-4mkiB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 10 ILE B 198
ILE B  38
GLY B  45
VAL B   5
LEU B  87
 None
None
SO4  B 301 (-3.4A)
None
None
 0.93A 3elzB-4mkiB:
undetectable		 3elzB-4mkiB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 10 ILE B 198
ILE B  38
GLY B  45
VAL B   5
LEU B  87
 None
None
SO4  B 301 (-3.4A)
None
None
 1.05A 3em0A-4mkiB:
undetectable		 3em0A-4mkiB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 8 ILE B 186
LEU B 183
LYS B  46
MET B 204
 LMT  B 302 ( 4.5A)
None
SO4  B 301 (-2.7A)
None
 1.05A 3selX-4mkiB:
undetectable		 3selX-4mkiB:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		3 / 3 SER B  44
ALA B  22
VAL B  21
 SO4  B 301 (-3.2A)
None
None
 0.54A 4o2bA-4mkiB:
undetectable		 4o2bA-4mkiB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		3 / 3 SER B  44
ALA B  22
VAL B  21
 SO4  B 301 (-3.2A)
None
None
 0.49A 4x1iA-4mkiB:
undetectable		 4x1iA-4mkiB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		4 / 4 VAL B  76
ILE B  64
ASN B  67
VAL B  85
 None
 1.02A 5ajqA-4mkiB:
undetectable		 5ajqA-4mkiB:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		3 / 3 SER B  44
ALA B  22
VAL B  21
 SO4  B 301 (-3.2A)
None
None
 0.45A 5eypA-4mkiB:
undetectable		 5eypA-4mkiB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 12 ILE B   3
ILE B 166
ILE B  50
PHE B  28
ILE B 207
 None
 1.11A 5hw8B-4mkiB:
undetectable
5hw8F-4mkiB:
undetectable
5hw8G-4mkiB:
undetectable		 5hw8B-4mkiB:
20.76
5hw8F-4mkiB:
20.76
5hw8G-4mkiB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		3 / 3 SER B  44
ALA B  22
VAL B  21
 SO4  B 301 (-3.2A)
None
None
 0.50A 5xiwC-4mkiB:
undetectable		 5xiwC-4mkiB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
(Caldanaerobacter
subterraneus) 		5 / 12 LEU B 243
GLN B  90
ILE B 182
LEU B 183
ILE B 207
 None
None
LMT  B 302 ( 4.0A)
None
None
 1.19A 5y2tB-4mkiB:
undetectable		 5y2tB-4mkiB:
undetectable