SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_A_EPAA1_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4mkm	PUTATIVE SURFACE ANCHORED PROTEIN (Clostridium perfringens)	5 / 12	VAL A 294 VAL A 162 GLY A 169 ALA A 175 LEU A 176	None	1.05A	3hs6A-4mkmA: undetectable	3hs6A-4mkmA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJT_D_017D101_2 (PROTEASE)	4mkm	PUTATIVE SURFACE ANCHORED PROTEIN (Clostridium perfringens)	5 / 9	LEU A 240 GLY A 243 ASP A 187 VAL A 162 ILE A 221	None	0.97A	4njtD-4mkmA: undetectable	4njtD-4mkmA: 14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCK_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4mkm	PUTATIVE SURFACE ANCHORED PROTEIN (Clostridium perfringens)	5 / 12	GLY A 236 ASN A 235 LEU A 240 ASP A 190 THR A 225	None	1.16A	4uckB-4mkmA: undetectable	4uckB-4mkmA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODI_G_ACTG702_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	4mkm	PUTATIVE SURFACE ANCHORED PROTEIN (Clostridium perfringens)	3 / 3	GLY A 231 THR A 229 ASN A 200	None	0.62A	5odiG-4mkmA: undetectable	5odiG-4mkmA: 19.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3HS6_A_EPAA1_1","PROSTAGLANDIN G\/H SYNTHASE 2","4mkm","PUTATIVE SURFACE ANCHORED PROTEIN","Clostridium perfringens",5,"VAL A 294;VAL A 162;GLY A 169;ALA A 175;LEU A 176","None","1.05A","3hs6A-4mkmA:undetectable","3hs6A-4mkmA:18.93"],["4NJT_D_017D101_2","PROTEASE","4mkm","PUTATIVE SURFACE ANCHORED PROTEIN","Clostridium perfringens",5,"LEU A 240;GLY A 243;ASP A 187;VAL A 162;ILE A 221","None","0.97A","4njtD-4mkmA:undetectable","4njtD-4mkmA:14.37"],["4UCK_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4mkm","PUTATIVE SURFACE ANCHORED PROTEIN","Clostridium perfringens",5,"GLY A 236;ASN A 235;LEU A 240;ASP A 190;THR A 225","None","1.16A","4uckB-4mkmA:undetectable","4uckB-4mkmA:23.81"],["5ODI_G_ACTG702_0","HETERODISULFIDE REDUCTASE, SUBUNIT A","4mkm","PUTATIVE SURFACE ANCHORED PROTEIN","Clostridium perfringens",3,"GLY A 231;THR A 229;ASN A 200","None","0.62A","5odiG-4mkmA:undetectable","5odiG-4mkmA:19.73"]]