SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 11 SER A 237
TRP A  12
TYR A  59
VAL A  51
PRO A  43
 None
 1.47A 1i9jH-4mknA:
undetectable
1i9jL-4mknA:
undetectable		 1i9jH-4mknA:
23.16
1i9jL-4mknA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 10 GLY A 211
VAL A 214
ALA A 183
ASN A 218
ILE A 228
 None
 1.09A 1likA-4mknA:
undetectable		 1likA-4mknA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		4 / 5 VAL A 163
GLU A 226
LYS A 253
PHE A   7
 None
 1.42A 3rv5C-4mknA:
undetectable
3rv5D-4mknA:
0.0		 3rv5C-4mknA:
15.56
3rv5D-4mknA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		4 / 8 LEU A 164
VAL A 186
TYR A 193
LEU A 206
 None
MRD  A 304 ( 4.2A)
None
None
 1.10A 3v81A-4mknA:
1.5		 3v81A-4mknA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 9 ALA A  63
ILE A  92
GLY A  10
VAL A  40
SER A  62
 None
 1.37A 4a3uA-4mknA:
7.4		 4a3uA-4mknA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		4 / 7 ILE A 124
GLY A   9
VAL A  40
SER A  62
 None
 0.88A 4a3uB-4mknA:
5.6		 4a3uB-4mknA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 12 ALA A  66
ILE A 124
LEU A  83
ALA A  80
VAL A  40
 None
 0.96A 4k6iA-4mknA:
undetectable		 4k6iA-4mknA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		3 / 3 LYS A 253
LYS A 220
SER A 223
 None
 1.11A 5odiA-4mknA:
undetectable		 5odiA-4mknA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		3 / 3 VAL A  41
TYR A  59
GLN A  60
 None
 0.55A 5qgkA-4mknA:
undetectable		 5qgkA-4mknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		3 / 3 VAL A  41
TYR A  59
GLN A  60
 None
 0.53A 5qgrA-4mknA:
undetectable		 5qgrA-4mknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		3 / 3 VAL A  41
TYR A  59
GLN A  60
 None
 0.56A 5qgtA-4mknA:
undetectable		 5qgtA-4mknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 12 MET A 147
LEU A 150
ILE A 208
LEU A 206
HIS A 187
 None
 1.11A 5toaB-4mknA:
undetectable		 5toaB-4mknA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 12 SER A  62
PHE A   7
VAL A 163
VAL A  40
THR A  84
 None
 0.85A 6djzC-4mknA:
undetectable		 6djzC-4mknA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4mkn TRIOSEPHOSPHATE
ISOMERASE
(Chlamydomonas
reinhardtii) 		5 / 11 VAL A  91
ALA A  80
GLU A 104
ALA A 116
LEU A 117
 None
 1.44A 6dk1B-4mknA:
undetectable		 6dk1B-4mknA:
19.86