SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 ILE A 284
GLY A 421
GLY A 171
ALA A 238
VAL A 141
 None
 1.25A 1i9gA-4mksA:
undetectable		 1i9gA-4mksA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 8 SER A 115
THR A 319
PHE A 350
LEU A 112
 None
 1.11A 1lhvA-4mksA:
undetectable		 1lhvA-4mksA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 10 GLY A 182
VAL A 149
ALA A 229
ALA A 225
ILE A 226
 None
 0.91A 1likA-4mksA:
undetectable		 1likA-4mksA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 8 GLU A 205
GLY A 392
SER A 366
ASP A 314
ASP A 242
 None
None
None
MG  A 502 (-3.1A)
MG  A 502 (-2.7A)
 1.50A 1m4iA-4mksA:
undetectable		 1m4iA-4mksA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 7 ALA A 178
TYR A 403
ILE A 167
PRO A 169
 None
 1.05A 1oniA-4mksA:
undetectable
1oniB-4mksA:
undetectable		 1oniA-4mksA:
17.02
1oniB-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 6 ALA A 178
TYR A 403
ILE A 167
PRO A 169
 None
 1.03A 1oniB-4mksA:
undetectable
1oniC-4mksA:
undetectable		 1oniB-4mksA:
17.02
1oniC-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 7 TYR A 403
ILE A 167
PRO A 169
ALA A 178
 None
 0.96A 1oniD-4mksA:
undetectable
1oniE-4mksA:
undetectable		 1oniD-4mksA:
17.02
1oniE-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 6 ALA A 178
TYR A 403
ILE A 167
PRO A 169
 None
 1.04A 1oniH-4mksA:
undetectable
1oniI-4mksA:
0.7		 1oniH-4mksA:
17.02
1oniI-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 LEU A 222
LEU A 305
VAL A 283
PHE A 219
ILE A 162
 None
 0.97A 1uobA-4mksA:
undetectable		 1uobA-4mksA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		3 / 3 ASP A 398
ARG A 396
ASP A  14
 None
 0.82A 1vptA-4mksA:
undetectable		 1vptA-4mksA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		3 / 3 LEU A 142
PRO A 143
LEU A 175
 None
 0.34A 2qd5B-4mksA:
undetectable		 2qd5B-4mksA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 8 LEU A 346
LEU A 116
THR A 321
GLY A 344
 None
 0.79A 3dcjB-4mksA:
undetectable		 3dcjB-4mksA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 4 LEU A 142
PRO A 143
LEU A 175
ARG A 408
 None
 1.39A 3hcoA-4mksA:
undetectable		 3hcoA-4mksA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 GLY A 230
VAL A 179
ARG A 180
PRO A 145
ASP A 236
 None
 1.09A 3m6vB-4mksA:
undetectable		 3m6vB-4mksA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 9 ILE A  75
ILE A 111
VAL A  79
THR A  93
ILE A  90
 None
 1.27A 3p4wB-4mksA:
undetectable		 3p4wB-4mksA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 8 VAL A 160
ILE A 162
ILE A 274
PHE A 219
 None
 0.87A 3uqbA-4mksA:
undetectable		 3uqbA-4mksA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 6 MET A 407
LEU A 175
PRO A 169
TYR A 419
 None
 1.36A 3vkxA-4mksA:
undetectable		 3vkxA-4mksA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 11 LEU A 112
SER A 115
ILE A 336
ILE A 338
LEU A 380
 None
 1.07A 3w67A-4mksA:
undetectable		 3w67A-4mksA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 GLU A 205
GLY A 370
TYR A 403
ASN A 148
VAL A 149
 None
None
None
CL  A 501 ( 4.5A)
None
 1.44A 4ffwA-4mksA:
undetectable		 4ffwA-4mksA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.10A 4j6dA-4mksA:
undetectable		 4j6dA-4mksA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.08A 4j6dB-4mksA:
undetectable		 4j6dB-4mksA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 12 PHE A 425
ALA A 240
VAL A 312
LEU A 337
GLN A 310
 None
 1.05A 4jbtA-4mksA:
undetectable		 4jbtA-4mksA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		6 / 10 SER A 115
ALA A  23
ILE A   7
VAL A  79
ALA A 110
ILE A  75
 None
 1.28A 4lbgA-4mksA:
2.3		 4lbgA-4mksA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 8 ARG A 399
ASP A 204
ALA A  41
SER A  42
 None
 1.06A 4lv9A-4mksA:
2.9
4lv9B-4mksA:
2.7		 4lv9A-4mksA:
23.70
4lv9B-4mksA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 11 ASP A  86
VAL A  25
ALA A 117
SER A 115
THR A  27
 None
 1.31A 4mmaA-4mksA:
undetectable		 4mmaA-4mksA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 5 ASN A 158
GLY A 152
ASP A 276
ASP A 161
 None
 0.91A 4n48B-4mksA:
undetectable		 4n48B-4mksA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		3 / 3 VAL A 364
GLU A 205
GLU A 164
 None
None
MG  A 502 ( 4.7A)
 0.91A 5jsdB-4mksA:
undetectable
5jsdC-4mksA:
undetectable		 5jsdB-4mksA:
20.80
5jsdC-4mksA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 6 GLY A  44
THR A  43
SER A  42
GLY A  40
 None
 0.86A 5k4pA-4mksA:
undetectable		 5k4pA-4mksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		4 / 8 PRO A 129
ALA A 139
ILE A 409
ALA A 412
 None
 0.71A 5mvmA-4mksA:
undetectable
5mvmB-4mksA:
undetectable		 5mvmA-4mksA:
11.65
5mvmB-4mksA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4mks ENOLASE 2
(Lactobacillus
gasseri) 		5 / 9 ALA A 122
GLU A 125
LEU A 126
GLY A 136
LEU A 134
 None
 1.38A 5wgqA-4mksA:
undetectable		 5wgqA-4mksA:
11.63