SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 10 GLY A 136
ALA A  95
HIS A  98
THR A 163
SER A 106
 None
FAD  A 601 (-3.7A)
IPA  A 604 ( 4.1A)
FAD  A 601 (-2.9A)
FAD  A 601 (-3.7A)
 1.41A 1gtfT-4mlaA:
undetectable
1gtfU-4mlaA:
0.5		 1gtfT-4mlaA:
9.98
1gtfU-4mlaA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 10 GLY A 136
ALA A  95
HIS A  98
THR A 163
SER A 106
 None
FAD  A 601 (-3.7A)
IPA  A 604 ( 4.1A)
FAD  A 601 (-2.9A)
FAD  A 601 (-3.7A)
 1.40A 1gtnO-4mlaA:
undetectable
1gtnP-4mlaA:
undetectable		 1gtnO-4mlaA:
9.98
1gtnP-4mlaA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		3 / 3 ASP A 397
LEU A 395
HIS A 371
 None
GOL  A 609 (-4.4A)
None
 0.61A 1qknA-4mlaA:
undetectable		 1qknA-4mlaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 7 TYR A 406
GLU A 269
LEU A 433
TYR A 469
 None
None
None
FAD  A 601 (-4.4A)
 1.07A 1tuvA-4mlaA:
4.2		 1tuvA-4mlaA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		3 / 3 ILE A 268
ASP A 254
PHE A 251
 None
 0.61A 1uwjB-4mlaA:
undetectable		 1uwjB-4mlaA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 12 ILE A 223
ILE A 502
VAL A 199
GLU A 191
ALA A  77
 FAD  A 601 (-4.6A)
None
None
None
None
 1.40A 1vq1A-4mlaA:
undetectable		 1vq1A-4mlaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		6 / 12 GLY A 166
GLY A  97
GLY A  99
GLU A 117
ILE A 224
VAL A 164
 FAD  A 601 (-3.6A)
FAD  A 601 (-3.4A)
FAD  A 601 ( 3.5A)
None
FAD  A 601 (-3.9A)
None
 1.38A 2oxtB-4mlaA:
undetectable		 2oxtB-4mlaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 12 LEU A 404
PHE A 271
LEU A 433
ARG A 353
GLN A 176
 IPA  A 610 (-4.8A)
None
None
None
None
 1.35A 2qd4B-4mlaA:
undetectable		 2qd4B-4mlaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 9 LEU A 503
ILE A 192
ALA A 214
GLU A 137
GLY A  97
 None
None
None
None
FAD  A 601 (-3.4A)
 1.23A 2v0mB-4mlaA:
undetectable		 2v0mB-4mlaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 4 THR A 417
VAL A 187
GLY A 172
THR A 157
 IPA  A 602 (-4.6A)
None
FAD  A 601 (-3.4A)
FAD  A 601 (-4.2A)
 1.05A 3cflA-4mlaA:
undetectable		 3cflA-4mlaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 6 THR A 163
ILE A 224
SER A 169
LEU A 168
 FAD  A 601 (-2.9A)
FAD  A 601 (-3.9A)
FAD  A 601 (-3.2A)
None
 0.96A 3deuB-4mlaA:
undetectable		 3deuB-4mlaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 8 LEU A 351
GLN A 176
TYR A 347
PHE A 350
 None
 1.11A 3po7A-4mlaA:
undetectable		 3po7A-4mlaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 12 GLY A  97
GLY A 166
THR A 167
VAL A 113
GLY A  99
 FAD  A 601 (-3.4A)
FAD  A 601 (-3.6A)
FAD  A 601 (-4.6A)
None
FAD  A 601 ( 3.5A)
 1.09A 3sglA-4mlaA:
undetectable		 3sglA-4mlaA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 5 LEU A 218
GLY A 219
PHE A 221
PHE A 490
 None
FAD  A 601 (-3.5A)
None
None
 1.17A 3smtA-4mlaA:
undetectable		 3smtA-4mlaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 8 ARG A 362
LEU A 359
TYR A 159
HIS A 161
 None
None
FAD  A 601 (-4.0A)
None
 1.36A 3zmdA-4mlaA:
undetectable
3zmdB-4mlaA:
undetectable		 3zmdA-4mlaA:
16.17
3zmdB-4mlaA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 11 GLY A 135
GLY A 136
VAL A 142
ASP A 132
ILE A 224
 FAD  A 601 ( 4.4A)
None
None
IPA  A 603 (-3.5A)
FAD  A 601 (-3.9A)
 1.12A 4pghA-4mlaA:
undetectable		 4pghA-4mlaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 12 ILE A 455
VAL A 390
ASN A 275
ASP A 397
ILE A 403
 None
 1.18A 5lg3J-4mlaA:
undetectable		 5lg3J-4mlaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 8 HIS A  42
LEU A  39
VAL A  66
SER A  44
 None
 1.00A 5m8rD-4mlaA:
undetectable		 5m8rD-4mlaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		6 / 12 GLY A 136
GLY A  97
ILE A 229
LEU A 168
GLY A 165
GLY A 135
 None
FAD  A 601 (-3.4A)
None
None
FAD  A 601 (-3.6A)
FAD  A 601 ( 4.4A)
 1.48A 5zhmB-4mlaA:
undetectable		 5zhmB-4mlaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		5 / 12 PRO A  69
LEU A 119
VAL A 113
VAL A 114
MET A  51
 None
 1.19A 6b52A-4mlaA:
undetectable		 6b52A-4mlaA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4mla CYTOKININ OXIDASE 2
(Zea
mays) 		4 / 8 GLN A 189
THR A 201
VAL A 200
SER A 208
 IPA  A 603 (-4.4A)
IPA  A 603 ( 4.5A)
None
None
 1.16A 6fbvC-4mlaA:
undetectable		 6fbvC-4mlaA:
17.84