SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.14A 1dhfB-4mlcA:
2.1		 1dhfB-4mlcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		4 / 8 PHE A 211
ILE A 220
LEU A 183
GLU A 184
 None
 0.87A 1eupA-4mlcA:
undetectable		 1eupA-4mlcA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 LEU A  96
ALA A  50
VAL A  97
LEU A 293
GLN A  73
 None
 1.35A 1kt6A-4mlcA:
undetectable		 1kt6A-4mlcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 LEU A  96
ALA A  50
VAL A  97
LEU A 293
GLN A  73
 None
 1.36A 1kt7A-4mlcA:
undetectable		 1kt7A-4mlcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.09A 1rx8A-4mlcA:
undetectable		 1rx8A-4mlcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ALA A  30
GLY A  26
LEU A  27
PHE A  23
PRO A 101
 None
 0.99A 1vpoH-4mlcA:
undetectable
1vpoL-4mlcA:
undetectable		 1vpoH-4mlcA:
20.56
1vpoL-4mlcA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		4 / 5 ALA A 201
PHE A 199
ILE A 126
ASP A 123
 None
 1.13A 1yc2D-4mlcA:
4.7		 1yc2D-4mlcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 GLU A  25
ALA A 283
ASP A 288
PRO A 279
PHE A 267
 None
 1.20A 2admA-4mlcA:
undetectable		 2admA-4mlcA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 GLU A  25
ALA A 283
ASP A 288
PRO A 279
PHE A 267
 None
 1.26A 2admB-4mlcA:
undetectable		 2admB-4mlcA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A  62
ALA A  63
GLY A  77
ILE A  83
GLY A  11
 None
 0.96A 2qe6B-4mlcA:
undetectable		 2qe6B-4mlcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 10 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.07A 2w3aB-4mlcA:
undetectable		 2w3aB-4mlcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.12A 3n0hA-4mlcA:
undetectable		 3n0hA-4mlcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		4 / 8 ILE A  90
GLN A  64
ALA A  61
LEU A  60
 None
 0.83A 3ozwA-4mlcA:
6.0		 3ozwA-4mlcA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		4 / 8 TYR A 282
ASP A  52
ALA A  54
SER A  18
 None
 1.11A 3rodA-4mlcA:
undetectable		 3rodA-4mlcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.14A 3s3vA-4mlcA:
undetectable		 3s3vA-4mlcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A  34
ALA A 289
LEU A  27
LEU A  47
ILE A  76
 None
 1.02A 3uvvA-4mlcA:
undetectable		 3uvvA-4mlcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 212
LEU A 224
MET A 142
VAL A 143
MET A 195
 None
 1.40A 3zqtA-4mlcA:
undetectable		 3zqtA-4mlcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 249
LEU A 224
MET A 142
VAL A 143
MET A 195
 None
 1.41A 3zqtA-4mlcA:
undetectable		 3zqtA-4mlcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 TYR A 282
SER A 253
TRP A  14
TYR A 151
GLY A 227
 None
None
None
SO4  A 402 ( 4.5A)
None
 1.30A 4ey7A-4mlcA:
3.2		 4ey7A-4mlcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 11 TYR A 282
SER A 253
TRP A  14
TYR A 151
GLY A 227
 None
None
None
SO4  A 402 ( 4.5A)
None
 1.30A 4ey7B-4mlcA:
2.6		 4ey7B-4mlcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.08A 4kfjB-4mlcA:
undetectable		 4kfjB-4mlcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		6 / 12 ASN A 119
ILE A 120
ILE A  10
LEU A  45
ILE A  76
ASN A  80
 None
None
None
None
None
SO4  A 402 (-4.6A)
 1.33A 4o1eA-4mlcA:
undetectable		 4o1eA-4mlcA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ASN A 119
ILE A 120
LEU A  45
ILE A  76
ASN A  80
 None
None
None
None
SO4  A 402 (-4.6A)
 1.15A 4o1eB-4mlcA:
undetectable		 4o1eB-4mlcA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 ILE A 200
ALA A 204
ILE A 126
LEU A 130
THR A 209
 None
 1.11A 4rgcA-4mlcA:
2.2		 4rgcA-4mlcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 10 LEU A 249
LEU A 155
ALA A 127
ALA A 201
GLY A 252
 None
 1.30A 4rn6A-4mlcA:
undetectable		 4rn6A-4mlcA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		4 / 6 ILE A 168
ALA A 131
LEU A 134
ILE A 225
 None
 0.81A 5mvmB-4mlcA:
undetectable
5mvmC-4mlcA:
undetectable		 5mvmB-4mlcA:
11.90
5mvmC-4mlcA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 10 TYR A 177
TYR A 145
ILE A 200
ILE A 198
ILE A 220
 None
 1.19A 5mzrA-4mlcA:
undetectable		 5mzrA-4mlcA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 10 TYR A 177
TYR A 145
ILE A 200
ILE A 198
ILE A 220
 None
 1.17A 5mzrC-4mlcA:
undetectable		 5mzrC-4mlcA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 10 ASN A 153
TYR A 176
ILE A 200
ILE A 225
LEU A 130
 None
 1.42A 5vkqA-4mlcA:
undetectable
5vkqB-4mlcA:
undetectable		 5vkqA-4mlcA:
12.39
5vkqB-4mlcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfitobacteri
um
hafniense) 		5 / 12 PHE A 199
LEU A 212
ILE A 220
LEU A 155
TYR A 151
 None
None
None
None
SO4  A 402 ( 4.5A)
 1.38A 5ycpA-4mlcA:
undetectable		 5ycpA-4mlcA:
13.55