SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4mld RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ILE A  31
ILE A  29
TYR A  55
ILE A  84
ALA A  82
 None
 1.23A 1jtxA-4mldA:
undetectable		 1jtxA-4mldA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4mld RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 PHE A  86
VAL A 102
ILE A  84
TYR A 100
 None
 0.93A 3pglA-4mldA:
3.2		 3pglA-4mldA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4mld RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 5 GLU A  58
LEU A   6
HIS A  62
GLY A  37
 None
 1.06A 3pp1A-4mldA:
undetectable		 3pp1A-4mldA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mld RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 4 VAL A  71
PHE A  86
PHE A  56
VAL A   3
 None
 1.37A 3rv5C-4mldA:
undetectable
3rv5D-4mldA:
undetectable		 3rv5C-4mldA:
17.36
3rv5D-4mldA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4mld RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ASP A 106
ARG A 120
ILE A  59
ILE A  84
ILE A  19
 None
 1.30A 6mkeA-4mldA:
undetectable
6mkeD-4mldA:
undetectable		 6mkeA-4mldA:
18.88
6mkeD-4mldA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4mld RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ASP A 106
ARG A 120
ILE A  59
ILE A  84
ILE A  19
 None
 1.16A 6mkeB-4mldA:
undetectable
6mkeC-4mldA:
undetectable		 6mkeB-4mldA:
18.88
6mkeC-4mldA:
18.88