SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mlg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 9 GLY A 241
ASP A  15
SER A 239
HIS A 274
MET A 135
 None
SO4  A 402 (-3.0A)
None
CA  A 401 ( 3.9A)
None
 1.29A 1gxsC-4mlgA:
0.0
1gxsD-4mlgA:
0.0		 1gxsC-4mlgA:
20.57
1gxsD-4mlgA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		3 / 3 ASP A  85
HIS A 289
ASP A  32
 CA  A 401 (-2.6A)
None
None
 0.89A 1nw5A-4mlgA:
undetectable		 1nw5A-4mlgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 12 ARG A 301
HIS A 244
GLY A 241
GLY A  43
MET A 135
 SO4  A 402 (-3.5A)
None
None
None
None
 1.48A 2y6rC-4mlgA:
undetectable		 2y6rC-4mlgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 11 LEU A 188
ILE A 129
PHE A 108
PHE A 151
SER A 225
 None
 1.50A 3ko0C-4mlgA:
undetectable
3ko0D-4mlgA:
undetectable
3ko0E-4mlgA:
undetectable
3ko0F-4mlgA:
undetectable		 3ko0C-4mlgA:
15.26
3ko0D-4mlgA:
15.26
3ko0E-4mlgA:
15.26
3ko0F-4mlgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 8 GLY A 156
PHE A 195
GLY A 152
PHE A 151
 None
 0.89A 3ko0O-4mlgA:
undetectable
3ko0Q-4mlgA:
undetectable		 3ko0O-4mlgA:
15.26
3ko0Q-4mlgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 11 LEU A 188
ILE A 129
PHE A 108
PHE A 151
SER A 225
 None
 1.49A 3ko0O-4mlgA:
undetectable
3ko0P-4mlgA:
undetectable
3ko0Q-4mlgA:
undetectable
3ko0R-4mlgA:
undetectable		 3ko0O-4mlgA:
15.26
3ko0P-4mlgA:
15.26
3ko0Q-4mlgA:
15.26
3ko0R-4mlgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 8 GLY A 152
PHE A 151
ILE A 107
PHE A 195
 None
 0.96A 3ko0O-4mlgA:
undetectable
3ko0Q-4mlgA:
undetectable		 3ko0O-4mlgA:
15.26
3ko0Q-4mlgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 11 ASP A  15
HIS A 288
VAL A 268
GLY A 270
LEU A 265
 SO4  A 402 (-3.0A)
None
None
None
None
 1.04A 3sm2B-4mlgA:
undetectable		 3sm2B-4mlgA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 12 LEU A  71
GLY A  68
HIS A  67
PRO A  29
LEU A 303
 None
 1.11A 3tm4A-4mlgA:
undetectable		 3tm4A-4mlgA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 12 LEU A  71
GLY A  68
HIS A  67
PRO A  29
LEU A 303
 None
 1.13A 3tm4B-4mlgA:
undetectable		 3tm4B-4mlgA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 5 GLU A 279
GLY A 282
TYR A 285
GLU A  60
 None
 1.34A 3w9tA-4mlgA:
undetectable		 3w9tA-4mlgA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 5 GLU A 279
GLY A 282
TYR A 285
GLU A  60
 None
 1.34A 3w9tC-4mlgA:
undetectable		 3w9tC-4mlgA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 5 GLU A 279
GLY A 282
TYR A 285
GLU A  60
 None
 1.34A 3w9tD-4mlgA:
undetectable		 3w9tD-4mlgA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 5 GLU A 279
GLY A 282
TYR A 285
GLU A  60
 None
 1.33A 3w9tG-4mlgA:
undetectable		 3w9tG-4mlgA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 6 GLU A 307
PRO A   4
LYS A   2
GLU A   3
 None
 1.34A 4a7tA-4mlgA:
undetectable		 4a7tA-4mlgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 6 GLU A 307
PRO A   4
LYS A   2
GLU A   3
 None
 1.29A 4a7tF-4mlgA:
undetectable		 4a7tF-4mlgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 6 GLU A 307
PRO A   4
LYS A   2
GLU A   3
 None
 1.31A 4a7uA-4mlgA:
undetectable		 4a7uA-4mlgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 10 ARG A 301
HIS A 244
GLY A 241
GLY A  43
MET A 135
 SO4  A 402 (-3.5A)
None
None
None
None
 1.42A 4a99A-4mlgA:
undetectable		 4a99A-4mlgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 11 ARG A 301
HIS A 244
GLY A 241
GLY A  43
MET A 135
 SO4  A 402 (-3.5A)
None
None
None
None
 1.43A 4a99B-4mlgA:
undetectable		 4a99B-4mlgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 11 ARG A 301
HIS A 244
GLY A 241
GLY A  43
MET A 135
 SO4  A 402 (-3.5A)
None
None
None
None
 1.44A 4a99C-4mlgA:
undetectable		 4a99C-4mlgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 11 ARG A 301
HIS A 244
GLY A 241
GLY A  43
MET A 135
 SO4  A 402 (-3.5A)
None
None
None
None
 1.44A 4a99D-4mlgA:
undetectable		 4a99D-4mlgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		3 / 3 GLY A  36
SER A  35
TRP A  33
 None
 0.71A 4e7cD-4mlgA:
undetectable		 4e7cD-4mlgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 12 ILE A 316
SER A 237
HIS A 288
LEU A 286
GLY A 321
 None
 1.07A 4ls7A-4mlgA:
undetectable
4ls7B-4mlgA:
undetectable		 4ls7A-4mlgA:
20.50
4ls7B-4mlgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 12 CYH A 182
ASN A 165
LEU A 159
LEU A 154
ALA A 180
 None
 1.42A 4rtbA-4mlgA:
undetectable		 4rtbA-4mlgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 12 ALA A  17
ASP A  87
MET A  13
LEU A 303
PRO A 100
 None
 1.25A 4xi3A-4mlgA:
undetectable		 4xi3A-4mlgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 5 THR A 298
GLY A 270
GLU A 223
HIS A 274
 None
None
SO4  A 402 (-3.3A)
CA  A 401 ( 3.9A)
 1.18A 5c0oH-4mlgA:
undetectable		 5c0oH-4mlgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 6 LYS A 102
ARG A  81
GLY A  43
ASP A  44
 None
 1.32A 5hp1A-4mlgA:
undetectable		 5hp1A-4mlgA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 6 HIS A 275
LEU A 286
CYH A 247
HIS A 288
 None
 1.25A 5hrqD-4mlgA:
undetectable
5hrqG-4mlgA:
undetectable
5hrqH-4mlgA:
undetectable		 5hrqD-4mlgA:
7.55
5hrqG-4mlgA:
5.43
5hrqH-4mlgA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		4 / 6 HIS A 275
LEU A 286
CYH A 247
HIS A 288
 None
 1.37A 5hrqD-4mlgA:
undetectable
5hrqG-4mlgA:
undetectable
5hrqH-4mlgA:
undetectable		 5hrqD-4mlgA:
7.55
5hrqG-4mlgA:
5.43
5hrqH-4mlgA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		5 / 10 LEU A 205
GLY A 256
VAL A 185
TYR A 150
TYR A 234
 None
 1.40A 5tqrB-4mlgA:
undetectable		 5tqrB-4mlgA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4mlg BETA-XYLOSIDASE
(uncultured
organism) 		3 / 3 GLY A  43
ASN A  42
ARG A  81
 None
 0.67A 5w7bD-4mlgA:
undetectable		 5w7bD-4mlgA:
13.38