SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mlo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A  59
LEU A 114
ILE A  58
ILE A  27
VAL A 131
 None
 1.05A 2ygqA-4mloA:
1.2		 2ygqA-4mloA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		5 / 11 LEU A  25
ILE A 222
PHE A 255
SER A 257
VAL A  83
 None
None
None
None
PAM  A 304 ( 4.8A)
 1.41A 3a9eB-4mloA:
undetectable		 3a9eB-4mloA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		4 / 6 ILE A 104
GLU A 156
LYS A 157
ASN A 160
 None
 1.07A 3kp6A-4mloA:
2.6
3kp6B-4mloA:
2.6		 3kp6A-4mloA:
23.22
3kp6B-4mloA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		4 / 5 VAL A 131
PHE A 148
ILE A  86
PHE A 152
 None
 0.99A 3owxB-4mloA:
undetectable		 3owxB-4mloA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		3 / 3 PHE A 147
LYS A 154
SER A 153
 None
 1.07A 3tyeB-4mloA:
undetectable		 3tyeB-4mloA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A  58
SER A  56
ILE A  79
LEU A  71
LEU A 114
 None
None
None
PAM  A 304 ( 4.9A)
None
 1.33A 3vw1B-4mloA:
3.5		 3vw1B-4mloA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		3 / 3 SER A 175
TYR A  26
ASP A  88
 None
 0.84A 4rp8C-4mloA:
undetectable		 4rp8C-4mloA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN
(Vibrio
cholerae) 		3 / 3 ASN A 185
PHE A 245
TYR A 224
 CL  A 301 (-4.3A)
None
None
 0.89A 4u15A-4mloA:
undetectable		 4u15A-4mloA:
21.14