SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		3 / 4 VAL A 246
TRP A 296
TRP A 273
 None
 1.26A 1gmkA-4mlzA:
undetectable
1gmkB-4mlzA:
undetectable		 1gmkA-4mlzA:
5.19
1gmkB-4mlzA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 ALA A 253
VAL A 246
GLY A 247
ALA A 284
ILE A 282
 None
 1.18A 1kxhA-4mlzA:
undetectable		 1kxhA-4mlzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 ASP A 293
GLY A 108
GLU A  89
SER A  85
TRP A 296
 None
 1.49A 1maaA-4mlzA:
undetectable		 1maaA-4mlzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 LEU A  90
LEU A  94
PHE A 205
LEU A 145
ASP A 144
 None
None
None
None
K  A 405 (-3.8A)
 1.20A 3gwuA-4mlzA:
undetectable		 3gwuA-4mlzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 LEU A  90
LEU A  94
PHE A 205
LEU A 145
THR A 103
 None
 1.28A 3gwuA-4mlzA:
undetectable		 3gwuA-4mlzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		4 / 8 ASP A 293
SER A 298
ASP A 327
ASP A 321
 None
 1.21A 3havA-4mlzA:
undetectable		 3havA-4mlzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		3 / 3 ILE A 198
SER A 213
SER A 209
 None
 0.63A 3iltH-4mlzA:
undetectable		 3iltH-4mlzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		3 / 3 ARG A 185
THR A  87
THR A 155
 None
 0.63A 3k2hB-4mlzA:
undetectable		 3k2hB-4mlzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 LEU A  62
PRO A  77
VAL A 201
GLY A 202
HIS A 208
 None
 1.23A 5nnaA-4mlzA:
undetectable		 5nnaA-4mlzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 LEU A  62
PRO A  77
VAL A 201
GLY A 202
HIS A 208
 None
 1.23A 5nnaB-4mlzA:
undetectable		 5nnaB-4mlzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 LEU A  62
PRO A  77
VAL A 201
GLY A 202
HIS A 208
 None
 1.22A 5nnaC-4mlzA:
undetectable		 5nnaC-4mlzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		5 / 12 LEU A  62
PRO A  77
VAL A 201
GLY A 202
HIS A 208
 None
 1.23A 5nnaD-4mlzA:
undetectable		 5nnaD-4mlzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4mlz PERIPLASMIC BINDING
PROTEIN
(Jonesia
denitrificans) 		4 / 6 ARG A 336
GLY A 334
GLU A  89
SER A  85
 None
 1.00A 5ny7A-4mlzA:
undetectable		 5ny7A-4mlzA:
24.09