SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 4 LEU A 361
LEU A 249
SER A 245
LEU A 354
 None
 1.12A 1ya3A-4mm0A:
undetectable		 1ya3A-4mm0A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 4 THR A  30
THR A  48
ASP A 315
ASP A 320
 None
 1.33A 2f8lA-4mm0A:
undetectable		 2f8lA-4mm0A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 10 THR A 288
THR A 297
VAL A  47
ILE A 294
VAL A  33
 None
 1.25A 2qboA-4mm0A:
43.2		 2qboA-4mm0A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 7 ILE A 106
LEU A 204
LEU A 345
GLY A 346
 None
None
HEM  A 401 ( 3.9A)
HEM  A 401 (-3.6A)
 0.96A 2qqcD-4mm0A:
undetectable
2qqcE-4mm0A:
undetectable		 2qqcD-4mm0A:
15.25
2qqcE-4mm0A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 7 VAL A  56
ARG A 286
GLY A  44
VAL A  33
 None
HEM  A 401 (-2.9A)
None
None
 0.94A 2y05A-4mm0A:
undetectable
2y05B-4mm0A:
undetectable		 2y05A-4mm0A:
24.07
2y05B-4mm0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 5 ILE A 116
PRO A 140
VAL A 223
PHE A 160
 None
 0.92A 2ygnA-4mm0A:
undetectable		 2ygnA-4mm0A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 8 PHE A 141
ALA A 117
ALA A 360
LEU A 266
 None
 0.94A 3l4dA-4mm0A:
30.1		 3l4dA-4mm0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 8 PHE A 141
ALA A 117
ALA A 360
LEU A 266
 None
 0.94A 3l4dD-4mm0A:
30.3		 3l4dD-4mm0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 12 ILE A 106
ALA A 350
GLU A 353
ILE A 146
LEU A 204
 None
HEM  A 401 ( 3.9A)
HEM  A 401 (-3.8A)
None
None
 1.20A 4cd2A-4mm0A:
undetectable		 4cd2A-4mm0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 6 LEU A 204
THR A 211
ALA A 207
SER A 202
 None
 0.94A 4pwjA-4mm0A:
undetectable		 4pwjA-4mm0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 9 ALA A 117
LEU A 368
LEU A 121
LEU A 361
ARG A 260
 None
 1.45A 4x30A-4mm0A:
undetectable		 4x30A-4mm0A:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 5 LEU A 121
ALA A 131
VAL A 246
ILE A 392
 None
 0.93A 4xe3A-4mm0A:
44.4		 4xe3A-4mm0A:
42.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		3 / 3 ASP A 165
SER A 239
TYR A 235
 None
 0.63A 5glmA-4mm0A:
undetectable		 5glmA-4mm0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		6 / 12 LEU A  46
ILE A 294
GLY A 295
ARG A  28
LEU A  27
ALA A  34
 None
 1.28A 5h5fA-4mm0A:
undetectable		 5h5fA-4mm0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 8 ILE A 229
LEU A 230
LEU A 150
MET A  83
 None
None
None
HEM  A 401 (-4.2A)
 0.89A 5u4sB-4mm0A:
undetectable		 5u4sB-4mm0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 12 PHE A 141
ALA A 360
GLY A 359
LEU A 137
ARG A 110
 None
 0.98A 5w7pA-4mm0A:
undetectable		 5w7pA-4mm0A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 9 VAL A 193
GLY A 191
ILE A 229
LEU A 230
ASP A 222
 None
 1.41A 6c2mC-4mm0A:
undetectable		 6c2mC-4mm0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 9 VAL A 394
VAL A 134
LEU A 370
LEU A 377
VAL A 246
 None
 1.19A 6czmA-4mm0A:
undetectable
6czmB-4mm0A:
undetectable		 6czmA-4mm0A:
25.74
6czmB-4mm0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		5 / 9 VAL A 394
VAL A 134
LEU A 370
LEU A 377
VAL A 246
 None
 1.19A 6czmB-4mm0A:
undetectable
6czmC-4mm0A:
undetectable		 6czmB-4mm0A:
25.74
6czmC-4mm0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4mm0 P450-LIKE
MONOOXYGENASE
(Streptomyces
griseoviridis) 		4 / 6 MET A 109
ARG A 351
ALA A 347
ALA A 103
 None
 1.01A 6fosB-4mm0A:
undetectable		 6fosB-4mm0A:
11.57